FMRI of brain activation in a genetic rat model of absence seizures
UMass Chan Affiliations
Department of PsychiatryCenter for Comparative Neuroimaging
Graduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2004-05-18Keywords
Animals; Brain; Brain Mapping; Cerebral Cortex; Disease Models, Animal; *Electroencephalography; Epilepsy, Absence; *Magnetic Resonance Imaging; Male; Neural Pathways; Oxygen; Rats; Rats, Wistar; Thalamic NucleiLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
PURPOSE: EEG-triggered functional magnetic resonance imaging (fMRI) was used to identify areas of brain activation during spontaneous spike-and-wave discharges (SWDs) in an epileptic rat strain under awake conditions. METHODS: Spontaneous absence seizures from 10 WAG/Rij rats were imaged by using T2*-weighted echo planar imaging at 4.7 Tesla. fMRI of the blood-oxygenation-level-dependent (BOLD) signal was triggered based on EEG recordings during imaging. Images obtained during spontaneous SWDs were compared with baseline images. RESULTS: Significant positive BOLD signal changes were apparent in several areas of the cortex and several important nuclei of the thalamus. In addition, no negative BOLD signal was found in any brain area. CONCLUSIONS: We have shown that EEG-triggered BOLD fMRI can be used to detect cortical and thalamic activation related to the spontaneous SWDs that characterize absence seizures in awake WAG/Rij rats. These results draw an anatomic correlation between areas in which increased BOLD signal is found and those in which SWDs have been recorded. In addition, no negative BOLD signal was found to be associated with these spontaneous SWDs. We also demonstrated the technical feasibility of using EEG-triggered fMRI in a genetic rat model of absence seizure.Source
Epilepsia. 2004 Jun;45(6):576-82. Link to article on publisher's siteDOI
10.1111/j.0013-9580.2004.39303.xPermanent Link to this Item
http://hdl.handle.net/20.500.14038/32682PubMed ID
15144421Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1111/j.0013-9580.2004.39303.x