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    rasiRNAs, DNA damage, and embryonic axis specification

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    Authors
    Theurkauf, William E.
    Klattenhoff, Carla Andrea
    Bratu, Diana P.
    Schultz, Nadine
    Koppetsch, Birgit S.
    Cook, Heather A.
    UMass Chan Affiliations
    Program in Molecular Medicine and Program in Cell Dynamics
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2007-03-27
    Keywords
    Animals; Body Patterning; *DNA Damage; Drosophila; Female; Genes, Insect; Microtubules; Models, Biological; Mutation; Oogenesis; RNA Interference; RNA, Small Interfering; Signal Transduction
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://doi.org/10.1101/sqb.2006.71.066
    Abstract
    Drosophila repeat-associated small interfering RNAs (rasiRNAs) have been implicated in retrotransposon and stellate locus silencing. However, mutations in the rasiRNA pathway genes armitage, spindle-E, and aubergine disrupt embryonic axis specification, triggering defects in microtubule organization and localization of osk and grk mRNAs during oogenesis. We show that mutations in mei-41 and mnk, which encode ATR and Chk2 kinases that function in DNA damage signal transduction, dramatically suppress the cytoskeletal and RNA localization defects associated with rasiRNA mutations. In contrast, stellate and retrotransposon silencing are not restored in mei-41 and mnk double mutants. We also find that armitage, aubergine, and spindle-E mutations lead to germ-line-specific accumulation of gamma-H2Av foci, which form at DNA double-strand breaks, and that mutations in armi lead to Chk2-dependent phosphorylation of Vasa, an RNA helicase required for axis specification. The Drosophila rasiRNA pathway thus appears to suppress DNA damage in the germ line, and mutations in this pathway block axis specification by activating an ATR/Chk2-dependent DNA damage response that disrupts microtubule polarization and RNA localization.
    Source

    Cold Spring Harb Symp Quant Biol. 2006;71:171-80. Link to article on publisher's site

    DOI
    10.1101/sqb.2006.71.066
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32689
    PubMed ID
    17381294
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1101/sqb.2006.71.066
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