Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer

Authors
Stein, Gary S.
Zaidi, Sayyed K.
Stein, Janet L.
Lian, Jane B.
Van Wijnen, Andre J.
Montecino, Martin A.
Young, Daniel W.
Javed, Amjad
Pratap, Jitesh
Choi, Je-Yong
Student Authors
Sandhya Pande
UMass Chan Affiliations
Department of Cell Biology
Document Type
Journal Article
Publication Date
2008-08-11
Keywords
Animals; Cell Nucleus; *Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Neoplasms; Transcription Factors
Cancer Biology
Cell Biology
Life Sciences
Medicine and Health Sciences

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Link to Full Text
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612589/pdf/nihms65880.pdf
Abstract
The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.
Source
J Cell Biochem. 2008 Aug 15;104(6):2016-26. Link to article on publisher's site
DOI
10.1002/jcb.21813
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32809
PubMed ID
18615590
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