Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer
AuthorsStein, Gary S.
Zaidi, Sayyed K.
Stein, Janet L.
Lian, Jane B.
Van Wijnen, Andre J.
Montecino, Martin A.
Young, Daniel W.
Ali, Syed A.
Hassan, Mohammad Q.
Student AuthorsSandhya Pande
UMass Chan AffiliationsDepartment of Cell Biology
Document TypeJournal Article
KeywordsAnimals; Cell Nucleus; *Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Neoplasms; Transcription Factors
Medicine and Health Sciences
MetadataShow full item record
AbstractThe regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.
SourceJ Cell Biochem. 2008 Aug 15;104(6):2016-26. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/32809
Related ResourcesLink to Article in PubMed