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dc.contributor.authorBrown, Elizabeth R.
dc.contributor.authorChi, Benjamin H.
dc.contributor.authorRead, Jennifer S.
dc.contributor.authorTaha, Taha E.
dc.contributor.authorSharma, Usha
dc.contributor.authorHoffman, Irving F.
dc.contributor.authorPikora, Cheryl A.
dc.contributor.authorGoldenberg, Robert L.
dc.contributor.authorFiscus, Susan A.
dc.date2022-08-11T08:08:51.000
dc.date.accessioned2022-08-23T16:09:55Z
dc.date.available2022-08-23T16:09:55Z
dc.date.issued2008-11-05
dc.date.submitted2009-02-19
dc.identifier.citationAIDS. 2008 Nov 12;22(17):2341-6. <a href="http://dx.doi.org/10.1097/QAD.0b013e328317cc15">Link to article on publisher's site</a>
dc.identifier.issn1473-5571 (Electronic)
dc.identifier.doi10.1097/QAD.0b013e328317cc15
dc.identifier.pmid18981773
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32814
dc.description.abstractOBJECTIVES: To determine the optimal time for a second HIV-1 nucleic acid amplification assay to detect late postnatal transmission of HIV-1 (first negative test at 4-8 weeks of age) in resource-limited settings. DESIGN: A longitudinal analysis of data from HIV Prevention Trial Network trial 024. METHODS: Children born to HIV-1-infected mothers enrolled in the HIV Prevention Trial Network trial 024 were tested for HIV-1 infection at six intervals within the first year of life. Mothers and infants received nevirapine prophylaxis. We estimated the probability of being alive and having a positive test in each interval after 4-8 weeks and at 30 days after weaning, conditional on having acquired HIV during the late postnatal period. The interval with the highest probability was taken to be the optimal visit interval. RESULTS: A total of 1609 infants from HIV Prevention Trial Network trial 024 had at least one HIV-1 diagnostic test and were included in the analysis. We found that testing at 1 month after weaning or 12 months of age (whichever comes first) identified 81% of those infected during the late postnatal period (after 4-8 weeks) through breastfeeding. In total, 93% (95% confidence interval 89, 98) of all infected infants would be detected if tests were performed at these two time points. CONCLUSION: In resource-limited settings, HIV-1 PCR testing at 4-8 weeks followed by a second test at 1 month after weaning or at 1 year of age (whichever comes first), led to the identification of the vast majority of HIV-1-infected infants.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18981773&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1097/QAD.0b013e328317cc15
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleDetermining an optimal testing strategy for infants at risk for mother-to-child transmission of HIV-1 during the late postnatal period
dc.typeJournal Article
dc.source.journaltitleAIDS (London, England)
dc.source.volume22
dc.source.issue17
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1369
dc.identifier.contextkey727564
html.description.abstract<p>OBJECTIVES: To determine the optimal time for a second HIV-1 nucleic acid amplification assay to detect late postnatal transmission of HIV-1 (first negative test at 4-8 weeks of age) in resource-limited settings.</p> <p>DESIGN: A longitudinal analysis of data from HIV Prevention Trial Network trial 024. METHODS: Children born to HIV-1-infected mothers enrolled in the HIV Prevention Trial Network trial 024 were tested for HIV-1 infection at six intervals within the first year of life. Mothers and infants received nevirapine prophylaxis. We estimated the probability of being alive and having a positive test in each interval after 4-8 weeks and at 30 days after weaning, conditional on having acquired HIV during the late postnatal period. The interval with the highest probability was taken to be the optimal visit interval.</p> <p>RESULTS: A total of 1609 infants from HIV Prevention Trial Network trial 024 had at least one HIV-1 diagnostic test and were included in the analysis. We found that testing at 1 month after weaning or 12 months of age (whichever comes first) identified 81% of those infected during the late postnatal period (after 4-8 weeks) through breastfeeding. In total, 93% (95% confidence interval 89, 98) of all infected infants would be detected if tests were performed at these two time points.</p> <p>CONCLUSION: In resource-limited settings, HIV-1 PCR testing at 4-8 weeks followed by a second test at 1 month after weaning or at 1 year of age (whichever comes first), led to the identification of the vast majority of HIV-1-infected infants.</p>
dc.identifier.submissionpathgsbs_sp/1369
dc.contributor.departmentProgram in Immunology and Virology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages2341-6


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