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UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2008-07-02Keywords
Animals; Axons; Brain; Fragile X Mental Retardation Protein; Gene Expression Regulation; Mice; Mice, Quaking; Myelin Sheath; Oligodendroglia; RNA-Binding Proteins; Signal TransductionLife Sciences
Medicine and Health Sciences
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Show full item recordAbstract
Myelin is a specialized structure of the nervous system that both enhances electrical conductance and protects neurons from degeneration. In the central nervous system, extensively polarized oligodendrocytes form myelin by wrapping cellular processes in a spiral pattern around neuronal axons. Myelin formation requires the oligodendrocyte to regulate gene expression in response to changes in its extracellular environment. Because these changes occur at a distance from the cell body, post-transcriptional control of gene expression allows the cell to fine-tune its response. Here, we review the RNA-binding proteins that control myelin formation in the brain, highlighting the molecular mechanisms by which they control gene expression and drawing parallels from studies in other cell types.Source
Biochim Biophys Acta. 2008 Aug;1779(8):486-94. Epub 2008 Jun 11. Link to article on publisher's siteDOI
10.1016/j.bbagrm.2008.06.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32831PubMed ID
18590840Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.bbagrm.2008.06.003