UMass Chan AffiliationsDepartment of Rheumatology
Graduate School of Biomedical Sciences
Document TypeJournal Article
KeywordsAdministration, Oral; Aged; Antibodies, Monoclonal; Antineoplastic Agents; Drug Therapy, Combination; Humans; Injections, Intra-Articular; Lymphoma, Mantle-Cell; Male; Methylprednisolone; Prednisolone; Serum Sickness; Treatment Outcome
Medicine and Health Sciences
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AbstractSerum sickness, an illness characterized by fever, rash, and arthralgias, can occur in patients who receive chimeric monoclonal antibody therapy. Rituximab, a B cell-depleting chimeric anti-CD20 monoclonal antibody, has been used with increasing frequency in the treatment of rheumatologic illnesses such as rheumatoid arthritis and systemic lupus erythematosus. Serum sickness has only rarely been reported following rituximab therapy. All prior reported cases have been in patients with autoimmune conditions. We describe a case of serum sickness in a patient treated with rituximab for mantle cell lymphoma. We also review the literature of rituximab-induced serum sickness.
J Rheumatol. 2007 Feb;34(2):430-3.