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dc.contributor.authorZimmerman, Wendy Cherie
dc.contributor.authorErikson, Raymond L.
dc.date2022-08-11T08:08:51.000
dc.date.accessioned2022-08-23T16:10:02Z
dc.date.available2022-08-23T16:10:02Z
dc.date.issued2007-06-15
dc.date.submitted2009-02-19
dc.identifier.citation<p>Cell Cycle. 2007 Jun 1;6(11):1314-8. Epub 2007 Jun 11.</p>
dc.identifier.issn1551-4005 (Electronic)
dc.identifier.doi10.4161/cc.6.11.4275
dc.identifier.pmid17568195
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32843
dc.description.abstractPolo-like kinases (Plks) are a highly conserved family of kinases found in flies, yeast and vertebrates. Plks derive their name from homology to the gene product of polo, a protein kinase first identified in Drosophila. Three polo-like kinases have been identified in vertebrates: Plk1, Plk2 and Plk3. Studies on Plk1 have revealed a great deal of information on its multiple functions, however Plk2 and Plk3 functions have not been fully explored. In this perspective we discuss recent work on Plk3 expression, function and localization in the context of previous reports on Plk3 and in terms of its relationship to Plk1.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17568195&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.4161/cc.6.11.4275
dc.subjectAnimals; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Cyclin E; Enzyme Induction; G1 Phase; Genes, Immediate-Early; Humans; Mammals; Mice; Mice, Knockout; Protein Structure, Tertiary; Protein-Serine-Threonine Kinases; purification; Proto-Oncogene Proteins; S Phase; Substrate Specificity; Vertebrates
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleFinding Plk3
dc.typeJournal Article
dc.source.journaltitleCell cycle (Georgetown, Tex.)
dc.source.volume6
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1399
dc.identifier.contextkey727652
html.description.abstract<p>Polo-like kinases (Plks) are a highly conserved family of kinases found in flies, yeast and vertebrates. Plks derive their name from homology to the gene product of polo, a protein kinase first identified in Drosophila. Three polo-like kinases have been identified in vertebrates: Plk1, Plk2 and Plk3. Studies on Plk1 have revealed a great deal of information on its multiple functions, however Plk2 and Plk3 functions have not been fully explored. In this perspective we discuss recent work on Plk3 expression, function and localization in the context of previous reports on Plk3 and in terms of its relationship to Plk1.</p>
dc.identifier.submissionpathgsbs_sp/1399
dc.contributor.departmentDepartment of Molecular and Cellular Biology
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages1314-8


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