Cancer targeting using tumor suppressor genes

Authors
Chada, Sunil
Menander, Kerstin B.
Bocangel, Dora B.
Roth, Jack A.
Ramesh, Rajagopal
UMass Chan Affiliations
Department of Molecular Genetics and Microbiology
Document Type
Journal Article
Publication Date
2007-11-06
Keywords
Animals; Antibodies, Monoclonal; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Gene Therapy; *Genes, Tumor Suppressor; *Genes, p53; Humans; Immunotherapy; Lung Neoplasms; Models, Biological; Neoplasms; Viral Vaccines
Life Sciences
Medicine and Health Sciences

Metadata
Show full item record
Link to Full Text
https://www.bioscience.org/2008/v13/af/2815/fulltext.htm
Abstract
Conventional cancer treatments include cytotoxic chemotherapies and radiotherapy, which result in significant collateral toxicities. The goal for future cancer treatments is to leverage improved understanding of cancer biology mechanisms and thereby develop targeted drugs that display exquisite tumor selectivity and avoid iatrogenic damage. In this review, we discuss the potential of tumor suppressor genes for development of cancer-selective drugs using the tumor suppressor p53 as an archetype.
Source

Front Biosci. 2008 Jan 1;13:1959-67.
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32863
PubMed ID
17981683
Related Resources

Link to Article in PubMed
Collections