Natural killer cells are not required for interferon-mediated prophylaxis against vaccinia or murine cytomegalovirus infections
Document Type
Journal ArticlePublication Date
1987-08-01Keywords
Animals; Cytomegalovirus Infections; Female; Interferon Type I; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Poly I-C; VacciniaLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Natural killer (NK) cell-depleted or control mice were treated prophylactically with polyinosinic: polycytidylic acid (polyI: polyC) or purified beta interferon (IFN) and then infected with either vaccinia virus or murine cytomegalovirus. NK cell depletion alone enhanced virus titres in the spleen and peritoneal cavity. However, poly I: polyC and IFN inhibited virus replication equally well in control and NK cell-depleted mice. This suggests that prophylactic IFN treatment mediates antiviral effects independently of NK cells.Source
J Gen Virol. 1987 Aug;68 ( Pt 8):2219-22.
DOI
10.1099/0022-1317-68-8-2219Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32866PubMed ID
3039047Related Resources
ae974a485f413a2113503eed53cd6c53
10.1099/0022-1317-68-8-2219