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Alu elements mediate MYB gene tandem duplication in human T-ALL

dc.contributor.authorO'Neil, Jennifer Elinor
dc.contributor.authorTchinda, Joelle
dc.contributor.authorGutierrez, Alejandro
dc.contributor.authorMoreau, Lisa A.
dc.contributor.authorMaser, Richard S.
dc.contributor.authorWong, Kwok-Kin
dc.contributor.authorLi, Wei
dc.contributor.authorMcKenna, Keith
dc.contributor.authorLiu, X. Shirley
dc.contributor.authorFeng, Bin
dc.contributor.authorNeuberg, Donna S.
dc.contributor.authorSilverman, Lewis B.
dc.contributor.authorDeAngelo, Daniel J.
dc.contributor.authorKutok, Jeffery L.
dc.contributor.authorRothstein, Rodney
dc.contributor.authorDePinho, Ronald A.
dc.contributor.authorChin, Lynda
dc.contributor.authorLee, Charles
dc.contributor.authorLook, A. Thomas
dc.date2022-08-11T08:08:51.000
dc.date.accessioned2022-08-23T16:10:09Z
dc.date.available2022-08-23T16:10:09Z
dc.date.issued2007-12-12
dc.date.submitted2009-02-19
dc.identifier.citationJ Exp Med. 2007 Dec 24;204(13):3059-66. Epub 2007 Dec 10. <a href="http://dx.doi.org/10.1084/jem.20071637">Link to article on publisher's site</a>
dc.identifier.issn1540-9538 (Electronic)
dc.identifier.doi10.1084/jem.20071637
dc.identifier.pmid18070937
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32867
dc.description.abstractRecent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats and that the duplication is mediated somatically by homologous recombination between the flanking Alu elements on sister chromatids. Nested long-range PCR analysis indicated a low frequency of homologous recombination leading to MYB tandem duplication in the peripheral blood mononuclear cells of approximately 50% of healthy individuals, none of whom had a MYB duplication in the germline. We conclude that Alu-mediated MYB tandem duplication occurs at low frequency during normal thymocyte development and is clonally selected during the molecular pathogenesis of human T-ALL.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18070937&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1084/jem.20071637
dc.subjectAlu Elements; Base Sequence; *Gene Duplication; Humans; In Situ Hybridization, Fluorescence; Leukemia-Lymphoma, Adult T-Cell; Models, Biological; Models, Genetic; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Proto-Oncogene Proteins c-myb; Recombination, Genetic
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleAlu elements mediate MYB gene tandem duplication in human T-ALL
dc.typeJournal Article
dc.source.journaltitleThe Journal of experimental medicine
dc.source.volume204
dc.source.issue13
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1420
dc.identifier.contextkey727709
html.description.abstract<p>Recent studies have demonstrated that the MYB oncogene is frequently duplicated in human T cell acute lymphoblastic leukemia (T-ALL). We find that the human MYB locus is flanked by 257-bp Alu repeats and that the duplication is mediated somatically by homologous recombination between the flanking Alu elements on sister chromatids. Nested long-range PCR analysis indicated a low frequency of homologous recombination leading to MYB tandem duplication in the peripheral blood mononuclear cells of approximately 50% of healthy individuals, none of whom had a MYB duplication in the germline. We conclude that Alu-mediated MYB tandem duplication occurs at low frequency during normal thymocyte development and is clonally selected during the molecular pathogenesis of human T-ALL.</p>
dc.identifier.submissionpathgsbs_sp/1420
dc.contributor.departmentDepartment of Molecular Genetics and Microbiology
dc.contributor.departmentDepartment of Pediatric Oncology
dc.source.pages3059-66


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