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    Beyond IP3: roles for higher order inositol phosphates in immune cell signaling

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    Authors
    Miller, Andrew Todd
    Chamberlain, Philip P.
    Cooke, Michael P.
    UMass Chan Affiliations
    Program in Immunology and Virology
    The Genomics Institute of the Novartis Research Foundation
    Document Type
    Journal Article
    Publication Date
    2008-02-01
    Keywords
    Animals; Inositol Phosphates; Lymphocytes; Mammals; *Models, Immunological; Signal Transduction
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://doi.org/10.4161/cc.7.4.5518
    Abstract
    Nearly 25 years ago the first function of an inositol phosphate, namely Ins(1,4,5)P3, was reported to act as a "second messenger" to mobilize calcium from the endoplasmic reticulum (ER). Since this discovery, many other inositol phosphates and the kinases and phosphatases that generate these inositol phosphates have subsequently been discovered. However, the function of these "higher order" inositol phosphates in biological processes, if any, has remained a mystery. Interest in higher order inositol phosphates, such as Ins(1,3,4,5)P4, was renewed this year following reports of novel roles for these molecules in distinct processes within the immune system ranging from T cell development, B cell development and tolerance induction, as well as neutrophil and mast cell function. In this review, we will touch upon recent advances in inositol phosphate function in mammalian cells. More specifically, we will highlight new studies that have identified novel functions for specific higher order inositol phosphates, such as Ins(1,3,4,5)P4, in the immune system.
    Source

    Cell Cycle. 2008 Feb 15;7(4):463-7. Epub 2008 Jan 3.

    DOI
    10.4161/cc.7.4.5518
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32885
    PubMed ID
    18235237
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.4161/cc.7.4.5518
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