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dc.contributor.authorMiller, Andrew Todd
dc.contributor.authorChamberlain, Philip P.
dc.contributor.authorCooke, Michael P.
dc.date2022-08-11T08:08:51.000
dc.date.accessioned2022-08-23T16:10:14Z
dc.date.available2022-08-23T16:10:14Z
dc.date.issued2008-02-01
dc.date.submitted2009-02-19
dc.identifier.citation<p>Cell Cycle. 2008 Feb 15;7(4):463-7. Epub 2008 Jan 3.</p>
dc.identifier.issn1551-4005 (Electronic)
dc.identifier.doi10.4161/cc.7.4.5518
dc.identifier.pmid18235237
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32885
dc.description.abstractNearly 25 years ago the first function of an inositol phosphate, namely Ins(1,4,5)P3, was reported to act as a "second messenger" to mobilize calcium from the endoplasmic reticulum (ER). Since this discovery, many other inositol phosphates and the kinases and phosphatases that generate these inositol phosphates have subsequently been discovered. However, the function of these "higher order" inositol phosphates in biological processes, if any, has remained a mystery. Interest in higher order inositol phosphates, such as Ins(1,3,4,5)P4, was renewed this year following reports of novel roles for these molecules in distinct processes within the immune system ranging from T cell development, B cell development and tolerance induction, as well as neutrophil and mast cell function. In this review, we will touch upon recent advances in inositol phosphate function in mammalian cells. More specifically, we will highlight new studies that have identified novel functions for specific higher order inositol phosphates, such as Ins(1,3,4,5)P4, in the immune system.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18235237&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.4161/cc.7.4.5518
dc.subjectAnimals; Inositol Phosphates; Lymphocytes; Mammals; *Models, Immunological; Signal Transduction
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleBeyond IP3: roles for higher order inositol phosphates in immune cell signaling
dc.typeJournal Article
dc.source.journaltitleCell cycle (Georgetown, Tex.)
dc.source.volume7
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1439
dc.identifier.contextkey727733
html.description.abstract<p>Nearly 25 years ago the first function of an inositol phosphate, namely Ins(1,4,5)P3, was reported to act as a "second messenger" to mobilize calcium from the endoplasmic reticulum (ER). Since this discovery, many other inositol phosphates and the kinases and phosphatases that generate these inositol phosphates have subsequently been discovered. However, the function of these "higher order" inositol phosphates in biological processes, if any, has remained a mystery. Interest in higher order inositol phosphates, such as Ins(1,3,4,5)P4, was renewed this year following reports of novel roles for these molecules in distinct processes within the immune system ranging from T cell development, B cell development and tolerance induction, as well as neutrophil and mast cell function. In this review, we will touch upon recent advances in inositol phosphate function in mammalian cells. More specifically, we will highlight new studies that have identified novel functions for specific higher order inositol phosphates, such as Ins(1,3,4,5)P4, in the immune system.</p>
dc.identifier.submissionpathgsbs_sp/1439
dc.contributor.departmentProgram in Immunology and Virology
dc.contributor.departmentThe Genomics Institute of the Novartis Research Foundation
dc.source.pages463-7


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