Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
Authors
Calvo, Jennifer AnnDaniels, Thomas G.
Wang, Xiaomei
Paul, Angelika C.
Lin, Jiandie
Spiegelman, Bruce M.
Stevenson, Susan C.
Rangwala, Shamina M.
UMass Chan Affiliations
Novartis Institutes for BioMedical ResearchDocument Type
Journal ArticlePublication Date
2008-02-02Keywords
Anaerobic Threshold; Animals; Citrate (si)-Synthase; DNA, Mitochondrial; Glucose Intolerance; Glycogen; Insulin Resistance; Male; Mice; Muscle, Skeletal; Oxygen Consumption; PPAR gamma; Physical Conditioning, Animal; Pulmonary Gas Exchange; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction; Running; Trans-ActivatorsLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
The induction of peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), a key regulator of mitochondriogenesis, is well-established under multiple physical exercise regimens, including, endurance, resistance, and sprint training. We wanted to determine if increased expression of PGC-1alpha in muscle is sufficient to improve performance during exercise in vivo. We demonstrate that muscle-specific expression of PGC-1alpha improves the performance during voluntary as well as forced exercise challenges. Additionally, PGC-1alpha transgenic mice exhibit an enhanced performance during a peak oxygen uptake exercise test, demonstrating an increased peak oxidative capacity, or whole body oxygen uptake. This increased ability to perform in multiple exercise paradigms is supported by enhanced mitochondrial function as suggested by increased mitochondrial gene expression, mitochondrial DNA, and mitochondrial enzyme activity. Thus this study demonstrates that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake.Source
J Appl Physiol. 2008 May;104(5):1304-12. Epub 2008 Jan 31. Link to article on publisher's siteDOI
10.1152/japplphysiol.01231.2007Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32887PubMed ID
18239076Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1152/japplphysiol.01231.2007