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dc.contributor.authorLengner, Christopher Joachim
dc.contributor.authorWelstead, G. Grant
dc.contributor.authorJaenisch, Rudolf
dc.date2022-08-11T08:08:51.000
dc.date.accessioned2022-08-23T16:10:15Z
dc.date.available2022-08-23T16:10:15Z
dc.date.issued2008-02-02
dc.date.submitted2009-02-19
dc.identifier.citation<p>Cell Cycle. 2008 Mar 15;7(6):725-8. Epub 2008 Jan 14.</p>
dc.identifier.issn1551-4005 (Electronic)
dc.identifier.doi10.4161/cc.7.6.5573
dc.identifier.pmid18239456
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32888
dc.description.abstractSince its discovery as a critical regulator of pluripotency in embryonic stem (ES) cells and the inner cells mass of the developing blastocyst, the Pou domain-containing transcription factor Oct4 has become a proxy for "stemness" in numerous studies of somatic stem cells as its presence is often taken as evidence of pluripotency in these cells. Recent studies, however, have demonstrated that not only is Oct4 dispensable for maintaining potency in somatic stem cell compartments, but also that the methods applied to detect Oct4 and the interpretation of the resulting data may be flawed. Here we contrast pathways known to govern pluripotency in embryonic stem cells with those in adult stem cells and critically discuss the concept of pluripotency in adult stem cells of the mammalian soma.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18239456&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.4161/cc.7.6.5573
dc.subjectAnimals; Embryonic Stem Cells; Humans; Mice; Octamer Transcription Factor-3; Pluripotent Stem Cells; Signal Transduction
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleThe pluripotency regulator Oct4: a role in somatic stem cells
dc.typeJournal Article
dc.source.journaltitleCell cycle (Georgetown, Tex.)
dc.source.volume7
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1441
dc.identifier.contextkey727736
html.description.abstract<p>Since its discovery as a critical regulator of pluripotency in embryonic stem (ES) cells and the inner cells mass of the developing blastocyst, the Pou domain-containing transcription factor Oct4 has become a proxy for "stemness" in numerous studies of somatic stem cells as its presence is often taken as evidence of pluripotency in these cells. Recent studies, however, have demonstrated that not only is Oct4 dispensable for maintaining potency in somatic stem cell compartments, but also that the methods applied to detect Oct4 and the interpretation of the resulting data may be flawed. Here we contrast pathways known to govern pluripotency in embryonic stem cells with those in adult stem cells and critically discuss the concept of pluripotency in adult stem cells of the mammalian soma.</p>
dc.identifier.submissionpathgsbs_sp/1441
dc.contributor.departmentThe Whitehead Institute for Biomedical Research
dc.source.pages725-8


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