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dc.contributor.authorWissinger, Erika L.
dc.contributor.authorStevens, Whitney W.
dc.contributor.authorVarga, Steven Michael
dc.contributor.authorBraciale, Thomas J.
dc.date2022-08-11T08:08:51.000
dc.date.accessioned2022-08-23T16:10:19Z
dc.date.available2022-08-23T16:10:19Z
dc.date.issued2008-02-23
dc.date.submitted2009-02-23
dc.identifier.citation<p>J Immunol. 2008 Mar 1;180(5):2957-66.</p>
dc.identifier.issn0022-1767 (Print)
dc.identifier.doi10.4049/jimmunol.180.5.2957
dc.identifier.pmid18292518
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32904
dc.description.abstractThe memory CD4+ T cell response to the respiratory syncytial virus (RSV) attachment (G) protein in the lungs of primed BALB/c mice undergoing challenge pulmonary RSV infection is dominated by effector T cells expressing a single Vbeta-chain, Vbeta14. We have used Vbeta14 expression to examine the kinetics of the activation, accumulation, and acquisition of the effector activity of memory CD4+ T cells responding to pulmonary infection. This analysis revealed that proliferative expansion and effector CD4+ T cell differentiation preferentially occur in the respiratory tract following rapid activation within and egress from the lymph nodes draining the respiratory tract. These findings suggest that, in response to natural infection at a peripheral mucosal site such as the lungs, memory CD4+ T cell expansion and differentiation into activated effector T cells may occur predominantly in the peripheral site of infection rather than exclusively in the lymph nodes draining the site of infection.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18292518&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.4049/jimmunol.180.5.2957
dc.subjectAnimals; CD4-Positive T-Lymphocytes; Cell Movement; *Cell Proliferation; Epitopes, T-Lymphocyte; Female; Genetic Vectors; Immunologic Memory; Kinetics; Lung; Mice; Mice, Inbred BALB C; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Vaccinia virus; Viral Envelope Proteins
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleProliferative expansion and acquisition of effector activity by memory CD4+ T cells in the lungs following pulmonary virus infection
dc.typeJournal Article
dc.source.journaltitleJournal of immunology (Baltimore, Md. : 1950)
dc.source.volume180
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1456
dc.identifier.contextkey733752
html.description.abstract<p>The memory CD4+ T cell response to the respiratory syncytial virus (RSV) attachment (G) protein in the lungs of primed BALB/c mice undergoing challenge pulmonary RSV infection is dominated by effector T cells expressing a single Vbeta-chain, Vbeta14. We have used Vbeta14 expression to examine the kinetics of the activation, accumulation, and acquisition of the effector activity of memory CD4+ T cells responding to pulmonary infection. This analysis revealed that proliferative expansion and effector CD4+ T cell differentiation preferentially occur in the respiratory tract following rapid activation within and egress from the lymph nodes draining the respiratory tract. These findings suggest that, in response to natural infection at a peripheral mucosal site such as the lungs, memory CD4+ T cell expansion and differentiation into activated effector T cells may occur predominantly in the peripheral site of infection rather than exclusively in the lymph nodes draining the site of infection.</p>
dc.identifier.submissionpathgsbs_sp/1456
dc.contributor.departmentThe Carter Immunology Center
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages2957-66


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