Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus-infected or interferon-treated mice
UMass Chan AffiliationsDepartment of Molecular Genetics and Microbiology
Department of Pathology
Graduate School of Biomedical Sciences
Document TypeJournal Article
KeywordsAnimals; Bone Marrow; Cells, Cultured; *Cytotoxicity, Immunologic; H-2 Antigens; Interferon Type I; Lymphocytic Choriomeningitis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes; T-Lymphocytes, Cytotoxic
Medicine and Health Sciences
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AbstractBone marrow cells and thymocytes isolated from virus-infected or interferon (IFN)-treated mice had marked increases in sensitivity to lysis by allospecific cytotoxic T lymphocytes (CTL) and in expression of class I histocompatibility antigens. Cultured fibroblasts treated with IFN in vitro yielded similar findings in addition to having increased sensitivity to lysis by virus-specific CTL. This indicates that virus-induced IFN may condition target cells in vivo for surveillance by CTL.
J Virol. 1986 Sep;59(3):735-9.