Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery
Authors
Montecino, Martin A.Stein, Gary S.
Stein, Janet L.
Lian, Jane B.
Van Wijnen, Andre J.
Carvallo, Loreto
Marcellini, Sylvain
Cruzat, Fernando
Arriagada, Gloria
Document Type
Journal ArticlePublication Date
2008-02-29Keywords
Animals; Bone Development; Cell Nucleus; *Gene Expression Regulation, Developmental; Humans; Models, Biological; Multiprotein Complexes; Transcription Factors; Vitamin DLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas co-regulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.Source
Crit Rev Eukaryot Gene Expr. 2008;18(2):163-72.
DOI
10.1615/CritRevEukarGeneExpr.v18.i2.50Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32909PubMed ID
18304030Related Resources
ae974a485f413a2113503eed53cd6c53
10.1615/CritRevEukarGeneExpr.v18.i2.50