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    Vitamin D control of gene expression: temporal and spatial parameters for organization of the regulatory machinery

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    Authors
    Montecino, Martin A.
    Stein, Gary S.
    Stein, Janet L.
    Lian, Jane B.
    Van Wijnen, Andre J.
    Carvallo, Loreto
    Marcellini, Sylvain
    Cruzat, Fernando
    Arriagada, Gloria
    UMass Chan Affiliations
    Department of Cell Biology
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2008-02-29
    Keywords
    Animals; Bone Development; Cell Nucleus; *Gene Expression Regulation, Developmental; Humans; Models, Biological; Multiprotein Complexes; Transcription Factors; Vitamin D
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://doi.org/10.1615/CritRevEukarGeneExpr.v18.i2.50
    Abstract
    Vitamin D is a principal modulator of skeletal gene expression, thus necessitating an understanding of interfaces between the activity of this steroid hormone and regulatory cascades that are functionally linked to the regulation of skeletal genes. Physiologic responsiveness requires combinatorial control, whereas co-regulatory proteins determine the specificity of biologic responsiveness to physiologic cues. It is becoming increasingly evident that regulatory complexes containing the vitamin D receptor are dynamic rather than static. Temporal and spatial modifications in the composition of these complexes provide a mechanism for integrating regulatory signals to support positive or negative control through synergism and antagonism. Compartmentalization of components of vitamin D control in nuclear microenvironments supports the integration of regulatory activities, perhaps by establishing thresholds for protein activity in time frames that are consistent with the execution of regulatory signaling.
    Source

    Crit Rev Eukaryot Gene Expr. 2008;18(2):163-72.

    DOI
    10.1615/CritRevEukarGeneExpr.v18.i2.50
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32909
    PubMed ID
    18304030
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1615/CritRevEukarGeneExpr.v18.i2.50
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