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UMass Chan Affiliations
Whitehead Institute for Biomedical ResearchGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2008-03-22Keywords
Animals; Disease; Humans; Nuclear Reprogramming; Pluripotent Stem Cells; Proto-Oncogene Proteins c-myc; Transcription FactorsLife Sciences
Medicine and Health Sciences
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Show full item recordAbstract
In metazoans, lineage-specific transcription factors and epigenetic modifiers function to establish and maintain proper gene expression programs during development. Recent landmark studies in both mouse and human have defined a set of transcription factors whose ectopic expression by retroviral transduction is capable of reprogramming a somatic nucleus to the pluripotent state. The identification of factors that are sufficient for the induction of pluripotency suggests that rewiring transcriptional regulatory networks at the molecular level can be used to manipulate cell fate in vitro. These findings have broad implications for understanding development and disease and for the potential use of stem cells in therapeutic applications.Source
Curr Opin Genet Dev. 2008 Apr;18(2):123-9. Epub 2008 Mar 20. Link to article on publisher's siteDOI
10.1016/j.gde.2008.01.013Permanent Link to this Item
http://hdl.handle.net/20.500.14038/32916PubMed ID
18356040Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.gde.2008.01.013