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dc.contributor.authorWelstead, G Grant
dc.contributor.authorSchorderet, Patrick
dc.contributor.authorBoyer, Laurie A.
dc.date2022-08-11T08:08:51.000
dc.date.accessioned2022-08-23T16:10:22Z
dc.date.available2022-08-23T16:10:22Z
dc.date.issued2008-03-22
dc.date.submitted2009-02-23
dc.identifier.citationCurr Opin Genet Dev. 2008 Apr;18(2):123-9. Epub 2008 Mar 20. <a href="http://dx.doi.org/10.1016/j.gde.2008.01.013">Link to article on publisher's site</a>
dc.identifier.issn0959-437X (Print)
dc.identifier.doi10.1016/j.gde.2008.01.013
dc.identifier.pmid18356040
dc.identifier.urihttp://hdl.handle.net/20.500.14038/32916
dc.description.abstractIn metazoans, lineage-specific transcription factors and epigenetic modifiers function to establish and maintain proper gene expression programs during development. Recent landmark studies in both mouse and human have defined a set of transcription factors whose ectopic expression by retroviral transduction is capable of reprogramming a somatic nucleus to the pluripotent state. The identification of factors that are sufficient for the induction of pluripotency suggests that rewiring transcriptional regulatory networks at the molecular level can be used to manipulate cell fate in vitro. These findings have broad implications for understanding development and disease and for the potential use of stem cells in therapeutic applications.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=18356040&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.gde.2008.01.013
dc.subjectAnimals; Disease; Humans; Nuclear Reprogramming; Pluripotent Stem Cells; Proto-Oncogene Proteins c-myc; Transcription Factors
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titleThe reprogramming language of pluripotency
dc.typeJournal Article
dc.source.journaltitleCurrent opinion in genetics and development
dc.source.volume18
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1468
dc.identifier.contextkey733765
html.description.abstract<p>In metazoans, lineage-specific transcription factors and epigenetic modifiers function to establish and maintain proper gene expression programs during development. Recent landmark studies in both mouse and human have defined a set of transcription factors whose ectopic expression by retroviral transduction is capable of reprogramming a somatic nucleus to the pluripotent state. The identification of factors that are sufficient for the induction of pluripotency suggests that rewiring transcriptional regulatory networks at the molecular level can be used to manipulate cell fate in vitro. These findings have broad implications for understanding development and disease and for the potential use of stem cells in therapeutic applications.</p>
dc.identifier.submissionpathgsbs_sp/1468
dc.contributor.departmentWhitehead Institute for Biomedical Research
dc.contributor.departmentGraduate School of Biomedical Sciences
dc.source.pages123-9


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