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    Vif and Apobec3G in the innate immune response to HIV: a tale of two proteins

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    Authors
    Farrow, Melissa Ann
    Sheehy, Ann M.
    UMass Chan Affiliations
    College of the Holy Cross
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2008-03-28
    Keywords
    Cytidine Deaminase; HIV; HIV Infections; Humans; *Immunity, Innate; Models, Biological; vif Gene Products, Human Immunodeficiency Virus
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.2217/17460913.3.2.145
    Abstract
    It is now 26 years after the first published report on HIV, and the global epidemic continues unabated, with estimates of over 33 million people currently infected, worldwide. Development of targeted therapies aimed at perturbing the HIV life cycle can be achieved only with a detailed comprehension of the dynamics of virus-host interactions within the cell. One such critical virus-host interaction is the recently elucidated interplay between the viral Vif protein and the innate immune defense molecule Apobec3G. Apobec3G potently suppresses HIV replication, but Vif can alleviate this inhibition, rescuing viral infectivity. Early work describing the characterization of Vif and the cloning and identification of Apobec3G as an antiviral are discussed. Recent advances detailing the mechanisms of the Vif-Apobec3G regulatory circuit and our nascent understanding of Apobec3G endogenous function are also presented. Collectively, these studies have shed light on potential novel therapeutic strategies aimed at exploiting Apobec3G antiviral function to abrogate HIV replication.
    Source
    Future Microbiol. 2008 Apr;3:145-54. Link to article on publisher's site
    DOI
    10.2217/17460913.3.2.145
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32919
    PubMed ID
    18366335
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.2217/17460913.3.2.145
    Scopus Count
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications

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