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    A DNA vaccine prime followed by a liposome-encapsulated protein boost confers enhanced mucosal immune responses and protection

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    Authors
    Yang, Kejian
    Whalen, Barbara J.
    Tirabassi, Rebecca S
    Selin, Liisa K.
    Levchenko, Tatyana S.
    Torchilin, Vladimir P.
    Kislauskis, Edward H.
    Guberski, Dennis L.
    UMass Chan Affiliations
    Department of Pathology
    Oral Vaccine Institute
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2008-04-22
    Keywords
    Administration, Intranasal; Animals; Animals, Newborn; Antibody Formation; Female; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Immunity, Mucosal; *Immunization, Secondary; Liposomes; Mice; Mice, Inbred BALB C; Th1 Cells; Vaccines, DNA; Vaccinia virus
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633597/
    Abstract
    A variety of DNA vaccine prime and recombinant viral boost immunization strategies have been developed to enhance immune responses in humans, but inherent limitations to these strategies exist. There is still an overwhelming need to develop safe and effective approaches that raise broad humoral and T cell-mediated immune responses systemically and on mucosal surfaces. We have developed a novel mucosal immunization regimen that precludes the use of viral vectors yet induces potent T cell responses. Using hepatitis B surface Ag (HBsAg), we observed that vaccination of BALB/c mice with an i.m. HBsAg-DNA vaccine prime followed by an intranasal boost with HBsAg protein encapsulated in biologically inert liposomes enhanced humoral and T cell immune responses, particularly on mucosal surfaces. Intranasal live virus challenge with a recombinant vaccinia virus expressing HBsAg revealed a correlation between T cell immune responses and protection of immunized mice. A shortened immunization protocol was developed that was successful in both adult and neonatal mice. These results support the conclusion that this new approach is capable of generating a Th-type-1-biased, broad spectrum immune response, specifically at mucosal surfaces. The success of this design may provide a safe and effective vaccination alternative for human use.
    Source

    J Immunol. 2008 May 1;180(9):6159-67.

    DOI
    10.4049/jimmunol.180.9.6159
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32935
    PubMed ID
    18424737
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.4049/jimmunol.180.9.6159
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