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    Improved pulmonary and growth outcomes in cystic fibrosis by newborn screening

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    Authors
    Collins, Melanie Sue
    Abbott, Mary-Alice
    Wakefield, Dorothy B.
    Lapin, Craig D.
    Drapeau, Ginny
    Hopfer, Sidney M.
    Greenstein, Robert M.
    Cloutier, Michelle M.
    UMass Chan Affiliations
    Department of Pediatrics
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2008-05-27
    Keywords
    Adolescent; Body Height; Body Weight; Child; *Child Development; Child, Preschool; Cystic Fibrosis; Female; Forced Expiratory Volume; Humans; Infant; Infant, Newborn; Lung; Male; Mass Screening; Time Factors; Vital Capacity
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1002/ppul.20842
    Abstract
    BACKGROUND: Newborn screening for cystic fibrosis (CF) is effective in improving long-term growth outcomes. However, there is conflicting evidence that early diagnosis maintains normal pulmonary function. Our goal was to determine if newborn screening results in improved longitudinal growth and maintenance of normal pulmonary function. METHODS: A retrospective study of individuals with CF born in Connecticut between 1983 and 1997 was conducted by medical record and CF Foundation Registry review. Growth, pulmonary function and bacterial acquisition/colonization data, from diagnosis through July 1, 2005, were compared in those diagnosed by newborn screen (n = 34) to those diagnosed by sweat test after symptom appearance (n = 21). RESULTS: Screened individuals demonstrated greater weight and height for age at diagnosis (P = 0.01 and 0.01) and through 15 years of age (P = 0.0002 and 0.01). Body mass index was higher in screened individuals (21 vs. 18 kg/m(2)) at 15 years of age (P = 0.01). At 15 years of age, screened individuals had a clinically higher forced expiratory volume in 1 second (FEV(1)) and forced vital capacity (FVC; 90% and 104% predicted) than non-screened individuals (74% and 91% predicted; P = 0.08 and 0.10). Over a 9-year period, from ages 6 to 15, percent predicted FEV(1) and FVC increased by 4% and 13% in screened individuals; and declined by 14% and 5% respectively in non-screened individuals (P = 0.01 and 0.02). Acquisition/colonization of Pseudomonas aeruginosa was similar between groups (P = 0.23). CONCLUSIONS: In this CF cohort, individuals diagnosed by newborn screening have improved growth and preservation of normal pulmonary function without increased risk of Pseudomonas aeruginosa colonization.
    Source
    Pediatr Pulmonol. 2008 Jul;43(7):648-55. Link to article on publisher's site
    DOI
    10.1002/ppul.20842
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/32955
    PubMed ID
    18500732
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/ppul.20842
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