The oxidation of methionine-54 of epoetinum alfa does not affect molecular structure or stability, but does decrease biological activity
UMass Chan Affiliations
Department of Biochemistry & Molecular PharmacologyGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2008-07-30Keywords
Allosteric Regulation; Cell Line; Circular Dichroism; Drug Stability; Epoetin Alfa; Hematinics; Hydrogen Peroxide; Methionine; Oxidation-Reduction; Protein Binding; Protein Folding; Temperature; Thermodynamics; tert-ButylhydroperoxideLife Sciences
Medicine and Health Sciences