Molecular switches involving homeodomain proteins, HOXA10 and RUNX2 regulate osteoblastogenesis
Authors
Hassan, Mohammad Q.Saini, Sharanjot
Gordon, Jonathan A. R.
Van Wijnen, Andre J.
Montecino, Martin A.
Stein, Janet L.
Stein, Gary S.
Lian, Jane B.
UMass Chan Affiliations
Department of Cell Biology and Cancer CenterGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2008-08-15
Metadata
Show full item recordAbstract
The osteoinductive BMP2 signal facilitates commitment to the osteoblast phenotype by inducing several classes of early response genes. Among these are bone-related HOX factors, homeodomain, RUNX and OSTERIX proteins. Here we demonstrate molecular events among BMP2-induced transcription factors that constitute a network of molecular switches on promoters of bone-related genes to coordinate their temporal expression during cellular differentiation. Our studies provide evidence for (1) selective association of HOXA10, MSX2, DLX3 and DLX5 homeodomain transcription factors on Runx2 and OC genes at stages of osteoblast maturation as well as (2) participation of these factors with RUNX2 in chromatin remodeling of bone-specific genes for repression, activation and attenuation of transcription. These findings reveal the requirement for multiple levels of control for the appropriate timing of osteoblast-related gene expression.Source
Cells Tissues Organs. 2009;189(1-4):122-5. Epub 2008 Aug 14. Link to article on publisher's siteDOI
10.1159/000151453Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33029PubMed ID
18701816; 18701816Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1159/000151453