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    A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response

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    Authors
    Pirri, Jennifer K.
    McPherson, Adam D.
    Donnelly, Jamie L.
    Francis, Michael M.
    Alkema, Mark J
    Student Authors
    Jennifer Pirri; Jamie Donnelly
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences, Neuroscience Program
    Francis Lab
    Alkema Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2009-05-28
    Keywords
    Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chloride Channels; Dose-Response Relationship, Drug; Electric Stimulation; Escape Reaction; Gene Expression; Green Fluorescent Proteins; Head Movements; Ion Channel Gating; Locomotion; Membrane Potentials; Mutation; Neck Muscles; Oocytes; Patch-Clamp Techniques; Physical Stimulation; Sequence Analysis, Protein; Tyramine; Xenopus laevis
    Neuroscience and Neurobiology
    
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804440/pdf/nihms114942.pdf
    Abstract
    A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. lgc-55 is expressed in neurons and muscle cells that receive direct synaptic inputs from tyraminergic motor neurons. Therefore, tyramine can act as a classical inhibitory neurotransmitter. Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response.
    Source
    Pirri, J.K., McPherson, A.D., Donnelly, J.L., Francis, M.M., and Alkema, M.J. (2009). A Tyramine-Gated Chloride Channel Coordinates Distinct Motor Programs of a Caenorhabditis elegans Escape Response. Neuron. 62, 528-536. Link to article on publisher's website
    DOI
    10.1016/j.neuron.2009.04.013
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33045
    PubMed ID
    19477154
    Notes

    Article's Supplemental Data include six figures and five movies and can be found with this article online.

    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.neuron.2009.04.013
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications
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