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    Cellular microRNA and P bodies modulate host-HIV-1 interactions

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    Authors
    Nathans, Robin S.
    Chu, Chia-ying
    Serquina, Anna Kristina
    Lu, Chih-Chung
    Cao, Hong
    Rana, Tariq M.
    UMass Chan Affiliations
    Program in Gene Function and Expression
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2009-06-30
    Keywords
    MicroRNAs; RNA-Induced Silencing Complex; HIV-1
    Life Sciences
    Medicine and Health Sciences
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.molcel.2009.06.003
    Abstract
    MicroRNAs (miRNAs), approximately 22 nt noncoding RNAs, assemble into RNA-induced silencing complexes (RISCs) and localize to cytoplasmic substructures called P bodies. Dictated by base-pair complementarity between miRNA and a target mRNA, miRNAs specifically repress posttranscriptional expression of several mRNAs. Here we report that HIV-1 mRNA interacts with RISC proteins and that disrupting P body structures enhances viral production and infectivity. In HIV-1-infected human T lymphocytes, we identified a highly abundant miRNA, miR-29a, which specifically targets the HIV-1 3'UTR region. Inhibiting miR-29a enhanced HIV-1 viral production and infectivity, whereas expressing a miR-29 mimic suppressed viral replication. We also found that specific miR-29a-HIV-1 mRNA interactions enhance viral mRNA association with RISC and P body proteins. Thus we provide an example of a single host miRNA regulating HIV-1 production and infectivity. These studies highlight the significance of miRNAs and P bodies in modulating host cell interactions with HIV-1 and possibly other viruses.
    Source
    Mol Cell. 2009 Jun 26;34(6):696-709. Link to article on publisher's site
    DOI
    10.1016/j.molcel.2009.06.003
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33073
    PubMed ID
    19560422
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.molcel.2009.06.003
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