Student Authors
Sri Devi NarasimhanUMass Chan Affiliations
Program in Gene Function and ExpressionDocument Type
Journal ArticlePublication Date
2009-12-01Keywords
Animals; Blood Proteins; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Forkhead Transcription Factors; Humans; Insulin; Insulin-Like Growth Factor I; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcription FactorsLife Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
Signal transduction pathways are tightly regulated by phosphorylation-dephosphorylation cycles and yet the mammalian genome contains far more genes that encode for protein kinases than protein phosphatases. Therefore, to target specific substrates, many phosphatases associate with distinct regulatory subunits and thereby modulate multiple cellular processes. One such example is the C. elegans PP2A regulatory subunit PPTR-1 that negatively regulates the insulin/insulin-like growth factor signaling pathway to modulate longevity, dauer diapause, fat metabolism and stress resistance. PPTR-1, as well as its mammalian homolog B56beta, specifically target the PP2A enzyme to AKT and mediate the dephosphorylation of this important kinase at a conserved threonine residue. In C. elegans, the major consequence of this modulation is activation of the FOXO transcription factor homolog DAF-16, which in turn regulates transcription of its many target genes involved in longevity and stress resistance. Understanding the function of B56 subunits may have important consequences in diseases such as Type 2 diabetes and cancer where the balance of Akt phosphorylation is deregulated.Source
Cell Cycle. 2009 Dec;8(23):3878-84.
DOI
10.4161/cc.8.23.10072Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33099PubMed ID
19901535Related Resources
ae974a485f413a2113503eed53cd6c53
10.4161/cc.8.23.10072