Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment
Student AuthorsKavitha Narayan
UMass Chan AffiliationsDepartment of Pathology
Graduate School of Biomedical Sciences, Immunology and Virology Program
Document TypeJournal Article
KeywordsT-Lymphocytes; Precursor Cells, T-Lymphoid; Genes, T-Cell Receptor; Wnt Proteins
T cell development
T cell lineage commitment
T cell receptor
γδ T cells
Immunology and Infectious Disease
Medicine and Health Sciences
MetadataShow full item record
AbstractThe mechanism of T cell precursor commitment to the gammadelta or alphabeta T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal.
Narayan K, Kang J., Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment., Semin Immunol. 2010 Aug;22(4):222-7. Epub 2010 May 6.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/33114