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    A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans

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    Authors
    Barbagallo, Belinda
    Prescott, Hilary A.
    Boyle, Patrick
    Climer, Jason
    Francis, Michael M.
    Student Authors
    Belinda Barbagallo; Hilary A. Prescott
    Jason Climer
    Academic Program
    Neuroscience
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences, Neuroscience Program
    Francis Lab
    Neurobiology
    Document Type
    Journal Article
    Publication Date
    2010-10-20
    Keywords
    Amino Acid Substitution; Animals; Behavior, Animal; Caenorhabditis elegans; Calnexin; Calreticulin; Cell Death; Genes, Reporter; Homeostasis; Ion Channels; Locomotion; Microscopy, Confocal; Motor Neuron Disease; Necrosis; Nerve Degeneration; Paralysis; Receptors, Nicotinic; Signal Transduction
    Neuroscience and Neurobiology
    
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    Link to Full Text
    http://dx.doi.org/10.1523/JNEUROSCI.1515-10.2010
    Abstract
    Inappropriate or excessive activation of ionotropic receptors can have dramatic consequences for neuronal function and, in many instances, leads to cell death. In Caenorhabditis elegans, nicotinic acetylcholine receptor (nAChR) subunits are highly expressed in a neural circuit that controls movement. Here, we show that heteromeric nAChRs containing the acr-2 subunit are diffusely localized in the processes of excitatory motor neurons and act to modulate motor neuron activity. Excessive signaling through these receptors leads to cell-autonomous degeneration of cholinergic motor neurons and paralysis. C. elegans double mutants lacking calreticulin and calnexin-two genes previously implicated in the cellular events leading to necrotic-like cell death (Xu et al. 2001)-are resistant to nAChR-mediated toxicity and possess normal numbers of motor neuron cell bodies. Nonetheless, excess nAChR activation leads to progressive destabilization of the motor neuron processes and, ultimately, paralysis in these animals. Our results provide new evidence that chronic activation of ionotropic receptors can have devastating degenerative effects in neurons and reveal that ion channel-mediated toxicity may have distinct consequences in neuronal cell bodies and processes.
    Source
    Barbagallo B, Prescott HA, Boyle P, Climer J, Francis, MM. (2010) A Dominant Mutation in a Neuronal Acetylcholine Receptor Subunit Leads to Motor Neuron Degeneration in Caenorhabditis elegans The Journal of Neuroscience, 30(42):13932-13942; doi:10.1523/JNEUROSCI.1515-10.2010. Link to article on publisher's website
    DOI
    10.1523/JNEUROSCI.1515-10.2010
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33137
    PubMed ID
    20962215
    Related Resources
    Link to article in PubMed
    Rights
    Copyright © 2010 the authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/.
    ae974a485f413a2113503eed53cd6c53
    10.1523/JNEUROSCI.1515-10.2010
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications
    Neurobiology Student Publications
    Neurobiology Faculty Publications

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