Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro
Student Authors
Elizabeth YuAcademic Program
MD/PhDUMass Chan Affiliations
Graduate School of Biomedical Sciences, MD/PhD ProgramWeaver Lab
Neurology
Neurobiology
Document Type
Journal ArticlePublication Date
2010-04-22Keywords
Casein Kinase Idelta; Circadian Rhythm; Suprachiasmatic Nucleus; MiceNeuroscience and Neurobiology
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Show full item recordAbstract
BACKGROUND: Casein kinase 1 delta (CK1delta) plays a more prominent role in the regulation of circadian cycle length than its homologue casein kinase 1 epsilon (CK1epsilon) in peripheral tissues such as liver and embryonic fibroblasts. Mice lacking CK1delta die shortly after birth, so it has not been possible to assess the impact of loss of CK1delta on behavioral rhythms controlled by the master circadian oscillator in the suprachiasmatic nuclei (SCN). METHODOLOGY/PRINCIPAL FINDINGS: In the present study, mPER2::LUCIFERASE bioluminescence rhythms were monitored from SCN explants collected from neonatal mice. The data demonstrate that SCN explants from neonatal CK1delta-deficient mice oscillate, but with a longer circadian period than littermate controls. The cycle length of rhythms recorded from neonatal SCN explants of CK1epsilon-deficient mice did not differ from control explants. CONCLUSIONS/SIGNIFICANCE: The results indicate that CK1delta plays a more prominent role than CK1epsilon in the maintenance of 24-hour rhythms in the master circadian oscillator.Source
Etchegaray J-P, Yu EA, Indic P, Dallmann R, Weaver DR (2010) Casein Kinase 1 Delta (CK1d) Regulates Period Length of the Mouse Suprachiasmatic Circadian Clock In Vitro. PLoS ONE 5(4): e10303. doi:10.1371/journal.pone.0010303. Link to article on publisher's websiteDOI
10.1371/journal.pone.0010303Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33146PubMed ID
20421981Related Resources
Link to article in PubMedRights
Copyright: © 2010 Etchegaray et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0010303