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    RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder

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    Authors
    Huang, Hsien-Sung
    Cheung, Iris
    Akbarian, Schahram
    Student Authors
    Hsien-Sung Huang
    UMass Chan Affiliations
    Department of Psychiatry, Brudnick Neuropsychiatric Research Institute
    Document Type
    Journal Article
    Publication Date
    2010-07-16
    Keywords
    Adolescent; Adult; Aged; Animals; Child; Child Development Disorders, Pervasive; Child, Preschool; Chromosomes, Human, Pair 15; Cohort Studies; Female; Gene Expression; Genetic Predisposition to Disease; Humans; Infant, Newborn; Interneurons; Male; Mice; Middle Aged; Prefrontal Cortex; Pregnancy; RNA Precursors; RNA, Transfer; Rats; Ribonuclease P; Transcription, Genetic; Young Adult
    Life Sciences
    Medicine and Health Sciences
    Neuroscience and Neurobiology
    
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    Link to Full Text
    http://dx.doi.org/10.1002/aur.141
    Abstract
    Dysfunction of cerebral cortex in autism is thought to involve alterations in inhibitory neurotransmission. Here, we screened, in prefrontal cortex (PFC) of 15 subjects diagnosed with autism and 15 matched controls the expression of 44 transcripts that are either preferentially expressed in gamma-aminobutyric acidergic interneurons of the mature cortex or important for the development of inhibitory circuitry. Significant alterations in the autism cohort included decreased expression (-45%) of RPP25 (15q24.1), which is located within the autism susceptibility locus, 15q22-26. RPP25, which encodes the 25 kDa subunit of ribonuclease P involved in tRNA and pre-ribosomal RNA processing, was developmentally regulated in cerebral cortex with peak levels of expression during late fetal development (human) or around birth (mouse). In the PFC, RPP25 chromatin showed high levels of histone H3-lysine 4 trimethylation, an epigenetic mark associated with transcriptional regulation. Unexpectedly, and in contrast to peripheral tissues, levels of RPP25 protein remained undetectable in fetal and adult cerebral cortex. Taken together, these findings suggest a potential role for the RPP25 gene transcript in the neurobiology of developmental brain disorders.
    Source
    Autism Res. 2010 Aug;3(4):153-61. Link to article on publisher's site
    DOI
    10.1002/aur.141
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33152
    PubMed ID
    20632321
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/aur.141
    Scopus Count
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    Morningside Graduate School of Biomedical Sciences Scholarly Publications

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