Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B
dc.contributor.author | Jiang, Yan | |
dc.contributor.author | Jakovcevski, Mira | |
dc.contributor.author | Bharadwaj, Rahul | |
dc.contributor.author | Connor, Caroline M. | |
dc.contributor.author | Schroeder, Frederick Albert | |
dc.contributor.author | Lin, Cong L. | |
dc.contributor.author | Straubhaar, Juerg R. | |
dc.contributor.author | Martin, Gilles E. | |
dc.contributor.author | Akbarian, Schahram | |
dc.date | 2022-08-11T08:08:54.000 | |
dc.date.accessioned | 2022-08-23T16:11:23Z | |
dc.date.available | 2022-08-23T16:11:23Z | |
dc.date.issued | 2010-05-28 | |
dc.date.submitted | 2011-05-20 | |
dc.identifier.citation | <p>J Neurosci. 2010 May 26;30(21):7152-67. <a href="http://dx.doi.org/10.1523/JNEUROSCI.1314-10.2010">Link to article on publisher's site</a></p> | |
dc.identifier.issn | 0270-6474 (Linking) | |
dc.identifier.doi | 10.1523/JNEUROSCI.1314-10.2010 | |
dc.identifier.pmid | 20505083 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/33153 | |
dc.description.abstract | Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. Chromatin immunoprecipitation in conjunction with DNA tiling arrays (ChIP-chip) revealed that genomic occupancies of neuronal Setdb1 are limited to | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=20505083&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.rights | Publisher PDF posted after 6 months as allowed by the publisher's author rights policy at http://www.jneurosci.org/sites/default/files/files/JN_License_to_Publish.pdf. | |
dc.subject | Adaptation, Ocular; Affect; Age Factors; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; Conditioning (Psychology); Electroshock; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Exploratory Behavior; Fear; Food Preferences; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Humans; Immobility Response, Tonic; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neurons; Patch-Clamp Techniques; Protein Methyltransferases; RNA, Small Interfering; Receptors, N-Methyl-D-Aspartate; Sucrose; Sweetening Agents; Transfection | |
dc.subject | Neuroscience and Neurobiology | |
dc.title | Setdb1 histone methyltransferase regulates mood-related behaviors and expression of the NMDA receptor subunit NR2B | |
dc.type | Journal Article | |
dc.source.journaltitle | The Journal of neuroscience : the official journal of the Society for Neuroscience | |
dc.source.volume | 30 | |
dc.source.issue | 21 | |
dc.identifier.legacyfulltext | https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2704&context=gsbs_sp&unstamped=1 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/1694 | |
dc.identifier.contextkey | 2022700 | |
refterms.dateFOA | 2022-08-23T16:11:23Z | |
html.description.abstract | <p>Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling and expressed in adult brain, but potential effects on neuronal function and behavior remain unexplored. Here, we report that transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. Chromatin immunoprecipitation in conjunction with DNA tiling arrays (ChIP-chip) revealed that genomic occupancies of neuronal Setdb1 are limited to</p> | |
dc.identifier.submissionpath | gsbs_sp/1694 | |
dc.contributor.department | Martin Lab | |
dc.contributor.department | Program in Molecular Medicine | |
dc.contributor.department | Brudnick Neuropsychiatric Research Institute | |
dc.contributor.department | Department of Psychiatry | |
dc.contributor.department | Graduate School of Biomedical Sciences | |
dc.source.pages | 7152-67 | |
dc.contributor.student | Yan Jiang; Caroline Connor; Frederick Schroeder |