The MutS C terminus is essential for mismatch repair activity in vivo

Authors
Calmann, Melissa A.
Nowosielska, Anetta
Marinus, Martin G.
UMass Chan Affiliations
Program in Molecular Medicine
Department of Biochemistry and Molecular Pharmacology
Graduate School of Biomedical Sciences
Document Type
Journal Article
Publication Date
2005-09-15
Keywords
Adenosine Triphosphatases; Bacterial Proteins; Base Pair Mismatch; DNA Repair; DNA-Binding Proteins; Escherichia coli; *Escherichia coli Proteins; MutS DNA Mismatch-Binding Protein; *Mutation
Life Sciences
Medicine and Health Sciences

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Link to Full Text
http://dx.doi.org/10.1128/JB.187.18.6577-6579.2005
Abstract
An Escherichia coli K-12 strain was constructed with a chromosomal deletion (mutSdelta800) in the mutS gene that produced the removal of the C-terminal 53 amino acids which are not present in the MutS crystal structure. This strain has a MutS null phenotype for mutation avoidance, anti-recombination, and sensitivity to cytotoxic agents in a dam mutant background.
Source
J Bacteriol. 2005 Sep;187(18):6577-9. Link to article on publisher's site
DOI
10.1128/JB.187.18.6577-6579.2005
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33170
PubMed ID
16159793
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