Neuronal death or dismemberment mediated by Sox14

Authors
Osterloh, Jeannette M.
Freeman, Marc R.
Student Authors
Jeannette Osterloh
UMass Chan Affiliations
Graduate School of Biomedical Sciences, Neuroscience Program
Freeman Lab
Neurobiology
Document Type
Journal Article
Publication Date
2009-11-26
Keywords
Animals; Axons; Cell Differentiation; Dendrites; Drosophila; Drosophila Proteins; Metamorphosis, Biological; Neurons; SOXB2 Transcription Factors
Neuroscience and Neurobiology

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Link to Full Text
http://dx.doi.org/10.1038/nn1209-1479
Abstract
The pruning of unneeded axons and dendrites is crucial for circuitry maturation, but poorly understood on the molecular level. During Drosophila metamorphosis, the transcription factor Sox14 acts as a context-dependent mediator of death, axonal or dendritic pruning. Its transcriptional target Mical acts specifically in dendrite pruning.
Source
Nat Neurosci. 2009 Dec;12(12):1479-80. Link to article on publisher's site
DOI
10.1038/nn1209-1479
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33176
PubMed ID
19935724
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