Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7
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UMass Chan Affiliations
Department of Molecular Genetics and MicrobiologyGraduate School of Biomedical Sciences
Document Type
Journal ArticlePublication Date
2003-03-05Keywords
Actins; Animals; Biological Transport; Escherichia coli; Escherichia coli O157; Escherichia coli Proteins; Humans; Oncogene Proteins; Receptors, Cell Surface; Signal TransductionLife Sciences
Medicine and Health Sciences
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Show full item recordAbstract
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 (EHEC) form characteristic lesions on infected mammalian cells called actin pedestals. Each of these two pathogens injects its own translocated intimin receptor (Tir) molecule into the plasma membranes of host cells. Interaction of translocated Tir with the bacterial outer membrane protein intimin is required to trigger the assembly of actin into focused pedestals beneath bound bacteria. Despite similarities between the Tir molecules and the host components that associate with pedestals, recent work indicates that EPEC and EHEC Tir are not functionally interchangeable. For EPEC, Tir-mediated binding of Nck, a host adaptor protein implicated in actin signaling, is both necessary and sufficient to initiate actin assembly. In contrast, for EHEC, pedestals are formed independently of Nck, and require translocation of bacterial factors in addition to Tir to trigger actin signaling.Source
Curr Opin Microbiol. 2003 Feb;6(1):82-90.
DOI
10.1016/S1369-5274(03)00005-5Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33212PubMed ID
12615225Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/S1369-5274(03)00005-5