CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections
Clute, Shalyn Catherine
Watkin, Levi B.
Saccoccio, Frances M.
Naumov, Yuri N.
Brehm, Michael A.
Welsh, Raymond M.
Selin, Liisa K.
Student AuthorsLevi B. Watkin
UMass Chan AffiliationsDepartment of Pathology
Document TypeJournal Article
KeywordsAdolescent; Adoptive Transfer; Animals; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Epitopes, T-Lymphocyte; Epstein-Barr Virus Infections; Humans; Immunity, Cellular; Immunologic Memory; Influenza, Human; Lymphocyte Activation; Lymphocytic Choriomeningitis; Male; Mice; Mice, Congenic; Mice, Inbred C57BL; Vaccinia; Young Adult
Immunology and Infectious Disease
Medicine and Health Sciences
MetadataShow full item record
AbstractIn this study, we demonstrate complex networks of CD8 T cell cross-reactivities between influenza A virus and EBV in humans and between lymphocytic choriomeningitis virus and vaccinia virus in mice. We also show directly that cross-reactive T cells mediate protective heterologous immunity in mice. Subsets of T cell populations reactive with one epitope cross-reacted with either of several other epitopes encoded by the same or the heterologous virus. Human T cells specific to EBV-encoded BMLF1(280-288) could be cross-reactive with two influenza A virus or two other EBV epitopes. Mouse T cells specific to the vaccinia virus-encoded a11r(198-205) could be cross-reactive with three different lymphocytic choriomeningitis virus, one Pichinde virus, or one other vaccinia virus epitope. Patterns of cross-reactivity differed among individuals, reflecting the private specificities of the host's immune repertoire and divergence in the abilities of T cell populations to mediate protective immunity. Defining such cross-reactive networks between commonly encountered human pathogens may facilitate the design of vaccines.
J Immunol. 2010 Mar 15;184(6):2825-38. Epub 2010 Feb 17.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/33243