PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors
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Authors
Sanchez-Gurmaches, JoanHung, Chien-Min
Sparks, Cynthia A.
Tang, Yuefeng
Li, Huawei
Guertin, David A.
Student Authors
Chien-Min HungUMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2012-09-05Keywords
Adipocytes; Adipose Tissue; Adipogenesis; Myogenic Regulatory Factor 5; PTEN PhosphohydrolaseCell and Developmental Biology
Life Sciences
Medicine and Health Sciences
Metadata
Show full item recordAbstract
The developmental origin of adipose tissue and what controls its distribution is poorly understood. By lineage tracing and gene expression analysis in mice, we provide evidence that mesenchymal precursors expressing Myf5-which are thought to give rise only to brown adipocytes and skeletal muscle-also give rise to a subset of white adipocytes. Furthermore, individual brown and white fats contain a mixture of adipocyte progenitor cells derived from Myf5(+) and Myf5(neg) lineages, the number of which varies with depot location. Subsets of white adipocytes originating from both Myf5(+) and Myf5(neg) precursors respond to β(3)-adrenoreceptor stimulation, suggesting "brite" adipocytes may also have multiple origins. We additionally find that deleting PTEN with myf5-cre causes lipomatosis and partial lipodystrophy by selectively expanding the Myf5(+) adipocyte lineages. Thus, the spectrum of adipocytes arising from Myf5(+) precursors is broader than previously thought, and differences in PI3K activity between adipocyte lineages alter body fat distribution.Source
Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, David A. Guertin. PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors. Cell Metabolism 2012 16(3):348-362. DOI 10.1016/j.cmet.2012.08.003. Link to article on publisher's site
DOI
10.1016/j.cmet.2012.08.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33259PubMed ID
22940198Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cmet.2012.08.003