Show simple item record

dc.contributor.authorSanchez-Gurmaches, Joan
dc.contributor.authorHung, Chien-Min
dc.contributor.authorSparks, Cynthia A.
dc.contributor.authorTang, Yuefeng
dc.contributor.authorLi, Huawei
dc.contributor.authorGuertin, David A.
dc.date2022-08-11T08:08:54.000
dc.date.accessioned2022-08-23T16:11:49Z
dc.date.available2022-08-23T16:11:49Z
dc.date.issued2012-09-05
dc.date.submitted2012-09-05
dc.identifier.citation<p>Joan Sanchez-Gurmaches, Chien-Min Hung, Cynthia A. Sparks, Yuefeng Tang, Huawei Li, David A. Guertin. PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors. Cell Metabolism 2012 16(3):348-362. DOI 10.1016/j.cmet.2012.08.003. <a href="http://dx.doi.org/10.1016/j.cmet.2012.08.003" target="_blank">Link to article on publisher's site</a></p>
dc.identifier.issn1932-7420
dc.identifier.doi10.1016/j.cmet.2012.08.003
dc.identifier.pmid22940198
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33259
dc.description.abstractThe developmental origin of adipose tissue and what controls its distribution is poorly understood. By lineage tracing and gene expression analysis in mice, we provide evidence that mesenchymal precursors expressing Myf5-which are thought to give rise only to brown adipocytes and skeletal muscle-also give rise to a subset of white adipocytes. Furthermore, individual brown and white fats contain a mixture of adipocyte progenitor cells derived from Myf5(+) and Myf5(neg) lineages, the number of which varies with depot location. Subsets of white adipocytes originating from both Myf5(+) and Myf5(neg) precursors respond to β(3)-adrenoreceptor stimulation, suggesting "brite" adipocytes may also have multiple origins. We additionally find that deleting PTEN with myf5-cre causes lipomatosis and partial lipodystrophy by selectively expanding the Myf5(+) adipocyte lineages. Thus, the spectrum of adipocytes arising from Myf5(+) precursors is broader than previously thought, and differences in PI3K activity between adipocyte lineages alter body fat distribution.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22940198&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.cmet.2012.08.003
dc.subjectAdipocytes; Adipose Tissue; Adipogenesis; Myogenic Regulatory Factor 5; PTEN Phosphohydrolase
dc.subjectCell and Developmental Biology
dc.subjectLife Sciences
dc.subjectMedicine and Health Sciences
dc.titlePTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors
dc.typeJournal Article
dc.source.journaltitleCell Metabolism
dc.source.volume16
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1792
dc.identifier.contextkey3293862
html.description.abstract<p>The developmental origin of adipose tissue and what controls its distribution is poorly understood. By lineage tracing and gene expression analysis in mice, we provide evidence that mesenchymal precursors expressing Myf5-which are thought to give rise only to brown adipocytes and skeletal muscle-also give rise to a subset of white adipocytes. Furthermore, individual brown and white fats contain a mixture of adipocyte progenitor cells derived from Myf5(+) and Myf5(neg) lineages, the number of which varies with depot location. Subsets of white adipocytes originating from both Myf5(+) and Myf5(neg) precursors respond to β(3)-adrenoreceptor stimulation, suggesting "brite" adipocytes may also have multiple origins. We additionally find that deleting PTEN with myf5-cre causes lipomatosis and partial lipodystrophy by selectively expanding the Myf5(+) adipocyte lineages. Thus, the spectrum of adipocytes arising from Myf5(+) precursors is broader than previously thought, and differences in PI3K activity between adipocyte lineages alter body fat distribution.</p>
dc.identifier.submissionpathgsbs_sp/1792
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages348-362
dc.contributor.studentChien-Min Hung


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record