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dc.contributor.authorMadera, Rachel F.
dc.contributor.authorLibraty, Daniel H.
dc.date2022-08-11T08:08:55.000
dc.date.accessioned2022-08-23T16:11:58Z
dc.date.available2022-08-23T16:11:58Z
dc.date.issued2013-01-01
dc.date.submitted2013-04-22
dc.identifier.citationVirus Res. 2013 Jan;171(1):216-21. doi: 10.1016/j.virusres.2012.12.004. <a href="http://dx.doi.org/10.1016/j.virusres.2012.12.004">Link to article on publisher's website</a>
dc.identifier.issn1872-7492
dc.identifier.doi10.1016/j.virusres.2012.12.004
dc.identifier.pmid23238076
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33294
dc.description.abstractA mouse model of heterosubtypic influenza A virus infections was used to determine the role of MyD88 signaling in CD4+ T-cell, CD8+ T-cell, and IgG immune responses. We found that MyD88 signaling played an important role in anti-influenza A virus heterosubtypic lung and spleen CD4+ T-cell, and spleen CD8+ T-cell, immune responses. MyD88 dependent signaling was important for T-helper 1 cytokine production in anti-influenza A virus lung and spleen heterosubtypic CD4+ T-cells, but not for their frequencies. Toll-like receptor 7 dependent signaling played a partial role in anti-influenza A virus lung heterosubtypic CD4+ T-helper 1 responses and anti-influenza A virus heterosubtypic IgG2c antibody levels. Our results have important implications for the generation of effective universal influenza vaccines.
dc.language.isoen_US
dc.publisherElsevier Science
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23238076&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.virusres.2012.12.004
dc.subjectMyeloid Differentiation Factor 88; Toll-Like Receptor 7; Influenza A virus
dc.subjectImmunology and Infectious Disease
dc.subjectVirology
dc.subjectVirus Diseases
dc.titleThe role of MyD88 signaling in heterosubtypic influenza A virus infections
dc.typeJournal Article
dc.source.journaltitleVirus research
dc.source.volume171
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1824
dc.identifier.contextkey4051578
html.description.abstract<p>A mouse model of heterosubtypic influenza A virus infections was used to determine the role of MyD88 signaling in CD4+ T-cell, CD8+ T-cell, and IgG immune responses. We found that MyD88 signaling played an important role in anti-influenza A virus heterosubtypic lung and spleen CD4+ T-cell, and spleen CD8+ T-cell, immune responses. MyD88 dependent signaling was important for T-helper 1 cytokine production in anti-influenza A virus lung and spleen heterosubtypic CD4+ T-cells, but not for their frequencies. Toll-like receptor 7 dependent signaling played a partial role in anti-influenza A virus lung heterosubtypic CD4+ T-helper 1 responses and anti-influenza A virus heterosubtypic IgG2c antibody levels. Our results have important implications for the generation of effective universal influenza vaccines.</p>
dc.identifier.submissionpathgsbs_sp/1824
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages216-21
dc.contributor.studentRachel Madera


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