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dc.contributor.authorCrisci, Jessica L.
dc.contributor.authorJensen, Jeffrey D.
dc.date2022-08-11T08:08:55.000
dc.date.accessioned2022-08-23T16:12:01Z
dc.date.available2022-08-23T16:12:01Z
dc.date.issued2012-05-15
dc.date.submitted2013-09-17
dc.identifier.citation<p>Crisci, J. L. and Jensen, J. D. 2012. Evolution of the Human Genome: Adaptive Changes. eLS. DOI: 10.1002/9780470015902.a0023987</p>
dc.identifier.doi10.1002/9780470015902.a0023987
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33306
dc.description.abstractThe study of human evolution is of interest to many both for the potential it has to improve our understanding of heritable disease, as well as for the possibility of illuminating evidence for adaptations that may help to tell the story of our origin. But uncovering evidence of positive selection at the genetic level has been a challenge. It remains unclear how much of the human genome has been affected by positive selection, what the main mechanism of selection is, and what types of patterns we should be looking for to identify adaptations. With whole-genome sequencing and high performance computation, we are quickly shifting to a field in which data is no longer a limiting factor. Here we will discuss the progress that has been made towards these ends, explore the best examples of human-specific adaptations to date, and discuss the implications of these findings within the context of classical population genetic theory.
dc.language.isoen_US
dc.relation.urlhttp://dx.doi.org/10.1002/9780470015902.a0023987
dc.subjectancient hominin genomes
dc.subjectdemography
dc.subjectgenome scans
dc.subjecthitchhiking
dc.subjecthuman adaptation
dc.subjecthuman evolution
dc.subjectselective sweeps
dc.subjectsoft sweeps
dc.subjectEvolution
dc.subjectGenomics
dc.subjectPopulation Biology
dc.titleEvolution of the Human Genome: Adaptive Changes
dc.typeJournal Article
dc.source.journaltitleeLS
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1835
dc.identifier.contextkey4593395
html.description.abstract<p>The study of human evolution is of interest to many both for the potential it has to improve our understanding of heritable disease, as well as for the possibility of illuminating evidence for adaptations that may help to tell the story of our origin. But uncovering evidence of positive selection at the genetic level has been a challenge. It remains unclear how much of the human genome has been affected by positive selection, what the main mechanism of selection is, and what types of patterns we should be looking for to identify adaptations. With whole-genome sequencing and high performance computation, we are quickly shifting to a field in which data is no longer a limiting factor. Here we will discuss the progress that has been made towards these ends, explore the best examples of human-specific adaptations to date, and discuss the implications of these findings within the context of classical population genetic theory.</p>
dc.identifier.submissionpathgsbs_sp/1835
dc.contributor.departmentProgram in Bioinformatics and Integrative Biology
dc.contributor.studentJessica L. Crisci


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