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    Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans

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    Authors
    Conine, Colin C.
    Moresco, James J.
    Gu, Weifeng
    Shirayama, Masaki
    Conte, Darryl Jr.
    Yates, John R. III
    Mello, Craig C.
    Student Authors
    Colin C. Conine
    UMass Chan Affiliations
    RNA Therapeutics Institute and Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2013-12-19
    Keywords
    Epigenetics
    RNAi
    Small RNA
    Argonaute
    Germline Sperm
    Bioinformatics
    Biology
    Cell Biology
    Developmental Biology
    Genetics
    Genomics
    Molecular Genetics
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    http://dx.doi.org/10.1016/j.cell.2013.11.032
    Abstract
    During each life cycle, germ cells preserve and pass on both genetic and epigenetic information. In C. elegans, the ALG-3/4 Argonaute proteins are expressed during male gametogenesis and promote male fertility. Here, we show that the CSR-1 Argonaute functions with ALG-3/4 to positively regulate target genes required for spermiogenesis. Our findings suggest that ALG-3/4 functions during spermatogenesis to amplify a small RNA signal that represents an epigenetic memory of male-specific gene expression. CSR-1, which is abundant in mature sperm, appears to transmit this memory to offspring. Surprisingly, in addition to small RNAs targeting male-specific genes, we show that males also harbor an extensive repertoire of CSR-1 small RNAs targeting oogenesis-specific mRNAs. Together, these findings suggest that C. elegans sperm transmit not only the genome but also epigenetic binary signals in the form of Argonaute/small RNA complexes that constitute a memory of gene expression in preceding generations.
    Source
    Conine, C.C., Moresco, J.J., Gu, W., Shirayama, M., Conte, D., Jr., Yates, J.R., 3rd, and Mello, C.C. (2013). Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans. Cell 155(7):1532-1544. doi: 10.1016/j.cell.2013.11.032. Link to article on publisher's website
    DOI
    10.1016/j.cell.2013.11.032
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33315
    PubMed ID
    24360276
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cell.2013.11.032
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