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    Histone Deacetylase 3 Modulates Tbx5 Activity to Regulate Early Cardiogenesis

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    Authors
    Lewandowski, Sara L.
    Janardhan, Harish P.
    Smee, Kevin M.
    Bachman, Marcos
    Sun, Zheng
    Lazar, Mitchell A.
    Trivedi, Chinmay M.
    Student Authors
    Sara L. Lewandowski; Harish P. Janardhan; Kevin M. Smee; Marcos Bachman
    UMass Chan Affiliations
    School of Medicine
    Department of Medicine, Division of Cardiovascular Medicine
    Document Type
    Journal Article
    Publication Date
    2014-03-05
    Keywords
    Histone deacetylase
    progenitor cells
    Holt-Oram Syndrome
    T-box gene
    heart development
    Cardiology
    Cell Biology
    Congenital, Hereditary, and Neonatal Diseases and Abnormalities
    Developmental Biology
    Laboratory and Basic Science Research
    Molecular Genetics
    Pediatrics
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    Link to Full Text
    https://doi.org/10.1093/hmg/ddu093
    Abstract
    Congenital heart defects often result from improper differentiation of cardiac progenitor cells. Although transcription factors involved in cardiac progenitor cell differentiation have been described, the associated chromatin modifiers in this process remain largely unknown. Here we show that mouse embryos lacking the chromatin-modifying enzyme histone deacetylase 3 (Hdac3) in cardiac progenitor cells exhibit precocious cardiomyocyte differentiation, severe cardiac developmental defects, upregulation of Tbx5 target genes and embryonic lethality. Hdac3 physically interacts with Tbx5 and modulates its acetylation to repress Tbx5-dependent activation of cardiomyocyte lineage-specific genes. These findings reveal that Hdac3 plays a critical role in cardiac progenitor cells to regulate early cardiogenesis.
    Source

    Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM. Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. Hum Mol Genet. 2014 Mar 5.

    DOI
    10.1093/hmg/ddu093
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33321
    PubMed ID
    24565863
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    Link to article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1093/hmg/ddu093
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