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    SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases

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    Authors
    Bennett, Gwendolyn M.
    Peterson, Craig L.
    Student Authors
    Gwendolyn Bennett
    UMass Chan Affiliations
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2015-06-01
    Keywords
    Biochemistry, Biophysics, and Structural Biology
    Cellular and Molecular Physiology
    Genetics and Genomics
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.dnarep.2015.03.006
    Abstract
    The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (gammaH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.
    Source
    DNA Repair (Amst). 2015 Jun;30:38-45. doi: 10.1016/j.dnarep.2015.03.006. Epub 2015 Mar 25. Link to article on publisher's site
    DOI
    10.1016/j.dnarep.2015.03.006
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33356
    PubMed ID
    25869823
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.dnarep.2015.03.006
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    Morningside GSBS Scholarly Publications

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