SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Student Authors
Gwendolyn BennettUMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2015-06-01Keywords
Biochemistry, Biophysics, and Structural BiologyCellular and Molecular Physiology
Genetics and Genomics
Metadata
Show full item recordAbstract
The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (gammaH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.Source
DNA Repair (Amst). 2015 Jun;30:38-45. doi: 10.1016/j.dnarep.2015.03.006. Epub 2015 Mar 25. Link to article on publisher's siteDOI
10.1016/j.dnarep.2015.03.006Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33356PubMed ID
25869823Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.dnarep.2015.03.006