SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases
dc.contributor.author | Bennett, Gwendolyn M. | |
dc.contributor.author | Peterson, Craig L. | |
dc.date | 2022-08-11T08:08:55.000 | |
dc.date.accessioned | 2022-08-23T16:12:15Z | |
dc.date.available | 2022-08-23T16:12:15Z | |
dc.date.issued | 2015-06-01 | |
dc.date.submitted | 2015-08-13 | |
dc.identifier.citation | DNA Repair (Amst). 2015 Jun;30:38-45. doi: 10.1016/j.dnarep.2015.03.006. Epub 2015 Mar 25. <a href="http://dx.doi.org/10.1016/j.dnarep.2015.03.006">Link to article on publisher's site</a> | |
dc.identifier.issn | 1568-7856 (Linking) | |
dc.identifier.doi | 10.1016/j.dnarep.2015.03.006 | |
dc.identifier.pmid | 25869823 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/33356 | |
dc.description.abstract | The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (gammaH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X. | |
dc.language.iso | en_US | |
dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25869823&dopt=Abstract">Link to Article in PubMed</a> | |
dc.relation.url | http://dx.doi.org/10.1016/j.dnarep.2015.03.006 | |
dc.subject | Biochemistry, Biophysics, and Structural Biology | |
dc.subject | Cellular and Molecular Physiology | |
dc.subject | Genetics and Genomics | |
dc.title | SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases | |
dc.type | Journal Article | |
dc.source.journaltitle | DNA repair | |
dc.source.volume | 30 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/gsbs_sp/1881 | |
dc.identifier.contextkey | 7457234 | |
html.description.abstract | <p>The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (gammaH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.</p> | |
dc.identifier.submissionpath | gsbs_sp/1881 | |
dc.contributor.department | Program in Molecular Medicine | |
dc.source.pages | 38-45 | |
dc.contributor.student | Gwendolyn Bennett |