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dc.contributor.authorBennett, Gwendolyn M.
dc.contributor.authorPeterson, Craig L.
dc.date2022-08-11T08:08:55.000
dc.date.accessioned2022-08-23T16:12:15Z
dc.date.available2022-08-23T16:12:15Z
dc.date.issued2015-06-01
dc.date.submitted2015-08-13
dc.identifier.citationDNA Repair (Amst). 2015 Jun;30:38-45. doi: 10.1016/j.dnarep.2015.03.006. Epub 2015 Mar 25. <a href="http://dx.doi.org/10.1016/j.dnarep.2015.03.006">Link to article on publisher's site</a>
dc.identifier.issn1568-7856 (Linking)
dc.identifier.doi10.1016/j.dnarep.2015.03.006
dc.identifier.pmid25869823
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33356
dc.description.abstractThe DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (gammaH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25869823&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.dnarep.2015.03.006
dc.subjectBiochemistry, Biophysics, and Structural Biology
dc.subjectCellular and Molecular Physiology
dc.subjectGenetics and Genomics
dc.titleSWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases
dc.typeJournal Article
dc.source.journaltitleDNA repair
dc.source.volume30
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/1881
dc.identifier.contextkey7457234
html.description.abstract<p>The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (gammaH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X.</p>
dc.identifier.submissionpathgsbs_sp/1881
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages38-45
dc.contributor.studentGwendolyn Bennett


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