Student Authors
Amanda L. HughesUMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyDocument Type
Journal ArticlePublication Date
2014-05-01Keywords
Animals; Chromatin Assembly and Disassembly; DNA; Eukaryota; Humans; NucleosomesBiochemistry
Biochemistry, Biophysics, and Structural Biology
Biophysics
Metadata
Show full item recordAbstract
It has been some 40 years since repeating subunits in eukaryotic chromatin, initially termed "nu bodies," were described. Four decades of study have characterized the structural organization of the nucleosome, from multiple crystal structures of individual nucleosomes to genome-wide maps of nucleosome positions in scores of organisms. Nucleosome positioning can impact essentially all DNA-templated processes, making an appreciation of the forces shaping the nucleosomal landscape in eukaryotes key to fully understanding genomic regulation. Here, we review the factors impacting nucleosome positioning and the ways that nucleosomes can control the output of the genome.Source
Annu Rev Biophys. 2014;43:41-63. doi: 10.1146/annurev-biophys-051013-023114. Link to article on publisher's siteDOI
10.1146/annurev-biophys-051013-023114Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33405PubMed ID
24702039Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1146/annurev-biophys-051013-023114