Morning and evening oscillators cooperate to reset circadian behavior in response to light input
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Student Authors
Pallavi LambaAcademic Program
NeuroscienceUMass Chan Affiliations
Graduate School of Biomedical Sciences, Neuroscience ProgramEmery Lab
Neurobiology
Document Type
Journal ArticlePublication Date
2014-05-08Keywords
Amino Acid Sequence; Animals; Circadian Rhythm; Cryptochromes; Drosophila; Drosophila Proteins; F-Box Proteins; *Light; Molecular Sequence Data; Mutagenesis; Neurons; RNA Interference; Sequence AlignmentBehavioral Neurobiology
Cell Biology
Cellular and Molecular Physiology
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Show full item recordAbstract
Light is a crucial input for circadian clocks. In Drosophila, short light exposure can robustly shift the phase of circadian behavior. The model for this resetting posits that circadian photoreception is cell autonomous: CRYPTOCHROME senses light, binds to TIMELESS (TIM), and promotes its degradation, which is mediated by JETLAG (JET). However, it was recently proposed that interactions between circadian neurons are also required for phase resetting. We identify two groups of neurons critical for circadian photoreception: the morning (M) and the evening (E) oscillators. These neurons work synergistically to reset rhythmic behavior. JET promotes acute TIM degradation cell autonomously in M and E oscillators but also nonautonomously in E oscillators when expressed in M oscillators. Thus, upon light exposure, the M oscillators communicate with the E oscillators. Because the M oscillators drive circadian behavior, they must also receive inputs from the E oscillators. Hence, although photic TIM degradation is largely cell autonomous, neural cooperation between M and E oscillators is critical for circadian behavioral photoresponses.Source
Cell Rep. 2014 May 8;7(3):601-8. doi: 10.1016/j.celrep.2014.03.044. Epub 2014 Apr 17. Link to article on publisher's siteDOI
10.1016/j.celrep.2014.03.044Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33427PubMed ID
24746814Related Resources
Link to Article in PubMedRights
Copyright © 2014 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2014.03.044