• Login
    View Item 
    •   Home
    • UMass Chan Student Research and Publications
    • Morningside Graduate School of Biomedical Sciences
    • Morningside GSBS Scholarly Publications
    • View Item
    •   Home
    • UMass Chan Student Research and Publications
    • Morningside Graduate School of Biomedical Sciences
    • Morningside GSBS Scholarly Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsProfilesView

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Injection molding of chondrocyte/alginate constructs in the shape of facial implants

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Chang, Sophia C. N.
    Rowley, Jon A.
    Tobias, Geoffrey
    Genes, Nicholas G.
    Roy, Amit K.
    Mooney, David J.
    Vacanti, Charles A.
    Bonassar, Lawrence J.
    UMass Chan Affiliations
    Graduate School of Biomedical Sciences
    Document Type
    Journal Article
    Publication Date
    2001-04-05
    Keywords
    Life Sciences
    
    Metadata
    Show full item record
    Link to Full Text
    https://doi.org/10.1002/1097-4636(20010615)55:4<503::AID-JBM1043>3.0.CO;2-S
    Abstract
    Over one million patients per year undergo some type of procedure involving cartilage reconstruction. Polymer hydrogels, such as alginate, have been shown to be effective carriers for chondrocytes in subcutaneous cartilage formation. The goal of our current study was to develop a method to create complex structures (nose bridge, chin, etc.) with good dimensional tolerance to form cartilage in specific shapes. Molds of facial implants were prepared using Silastic ERTV. Suspensions of chondrocytes in 2% alginate were gelled by mixing with CaSO(4) (0.2 g/mL) and injected into the molds. Constructs of various cell concentrations (10, 25, and 50 million/mL) were implanted in the dorsal aspect of nude mice and harvested at times up to 30 weeks. Analysis of implanted constructs indicated progressive cartilage formation with time. Proteoglycan and collagen constructs increased with time to approximately 60% that of native tissue. Equilibrium modulus likewise increased with time to 15% that of normal tissue, whereas hydraulic permeability decreased to 20 times that of native tissue. Implants seeded with greater concentrations of cells increased proteoglycan content and collagen content and equilibrium and decreased permeability. Production of shaped cartilage implants by this technique presents several advantages, including good dimensional tolerance, high sample-to-sample reproducibility, and high cell viability. This system may be useful in the large-scale production of precisely shaped cartilage implants. 2001
    Source

    J Biomed Mater Res. 2001 Jun 15;55(4):503-11.

    DOI
    10.1002/1097-4636(20010615)55:4<503::AID-JBM1043>3.0.CO;2-S
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33441
    PubMed ID
    11288078
    Related Resources

    Link to article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1002/1097-4636(20010615)55:4<503::AID-JBM1043>3.0.CO;2-S
    Scopus Count
    Collections
    Morningside GSBS Scholarly Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Works found in eScholarship@UMassChan are protected by copyright unless otherwise indicated.
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.