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dc.contributor.authorLi, Qi
dc.contributor.authorMana-Capelli, Sebastian
dc.contributor.authorRoth Flach, Rachel J.
dc.contributor.authorDanai, Laura V.
dc.contributor.authorAmcheslavsky, Alla
dc.contributor.authorNie, Yingchao
dc.contributor.authorKaneko, Satoshi
dc.contributor.authorYao, Xiaohao
dc.contributor.authorChen, Xiaochu
dc.contributor.authorCotton, Jennifer L.
dc.contributor.authorMao, Junhao
dc.contributor.authorMcCollum, Dannel
dc.contributor.authorCzech, Michael P.
dc.contributor.authorXu, Lan
dc.contributor.authorIp, Y. Tony
dc.date2022-08-11T08:08:56.000
dc.date.accessioned2022-08-23T16:12:54Z
dc.date.available2022-08-23T16:12:54Z
dc.date.issued2014-11-10
dc.date.submitted2017-09-06
dc.identifier.citation<p>Dev Cell. 2014 Nov 10;31(3):291-304. doi: 10.1016/j.devcel.2014.09.012. Epub 2014 Nov 10. <a href="https://doi.org/10.1016/j.devcel.2014.09.012">Link to article on publisher's site</a></p>
dc.identifier.issn1534-5807 (Linking)
dc.identifier.doi10.1016/j.devcel.2014.09.012
dc.identifier.pmid25453828
dc.identifier.urihttp://hdl.handle.net/20.500.14038/33495
dc.description<p>Full author list omitted for brevity. For full list of authors see article.</p>
dc.description.abstractSimilar to the mammalian intestine, the Drosophila adult midgut has resident stem cells that support growth and regeneration. How the niche regulates intestinal stem cell activity in both mammals and flies is not well understood. Here, we show that the conserved germinal center protein kinase Misshapen restricts intestinal stem cell division by repressing the expression of the JAK-STAT pathway ligand Upd3 in differentiating enteroblasts. Misshapen, a distant relative to the prototypic Warts activating kinase Hippo, interacts with and activates Warts to negatively regulate the activity of Yorkie and the expression of Upd3. The mammalian Misshapen homolog MAP4K4 similarly interacts with LATS (Warts homolog) and promotes inhibition of YAP (Yorkie homolog). Together, this work reveals that the Misshapen-Warts-Yorkie pathway acts in enteroblasts to control niche signaling to intestinal stem cells. These findings also provide a model in which to study requirements for MAP4K4-related kinases in MST1/2-independent regulation of LATS and YAP.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=25453828&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254555/
dc.subjectUMCCTS funding
dc.subjectCell Biology
dc.subjectDevelopmental Biology
dc.titleThe conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila
dc.typeJournal Article
dc.source.journaltitleDevelopmental cell
dc.source.volume31
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/gsbs_sp/2020
dc.identifier.contextkey10714525
html.description.abstract<p>Similar to the mammalian intestine, the Drosophila adult midgut has resident stem cells that support growth and regeneration. How the niche regulates intestinal stem cell activity in both mammals and flies is not well understood. Here, we show that the conserved germinal center protein kinase Misshapen restricts intestinal stem cell division by repressing the expression of the JAK-STAT pathway ligand Upd3 in differentiating enteroblasts. Misshapen, a distant relative to the prototypic Warts activating kinase Hippo, interacts with and activates Warts to negatively regulate the activity of Yorkie and the expression of Upd3. The mammalian Misshapen homolog MAP4K4 similarly interacts with LATS (Warts homolog) and promotes inhibition of YAP (Yorkie homolog). Together, this work reveals that the Misshapen-Warts-Yorkie pathway acts in enteroblasts to control niche signaling to intestinal stem cells. These findings also provide a model in which to study requirements for MAP4K4-related kinases in MST1/2-independent regulation of LATS and YAP.</p>
dc.identifier.submissionpathgsbs_sp/2020
dc.contributor.departmentDepartment of Cancer Biology
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.contributor.departmentProgram in Molecular Medicine
dc.source.pages291-304
dc.contributor.studentLaura V. Danai


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