Student Authors
Chien-Min HungUMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2012-12-01
Metadata
Show full item recordAbstract
The mechanistic target of rapamycin (mTOR) kinase is a conserved regulator of cell growth, proliferation, and survival. In cells, mTOR is the catalytic subunit of two complexes called mTORC1 and mTORC2, which have distinct upstream regulatory signals and downstream substrates. mTORC1 directly senses cellular nutrient availability while indirectly sensing circulating nutrients through growth factor signaling pathways. Cellular stresses that restrict growth also impinge on mTORC1 activity. mTORC2 is less well understood and appears only to sense growth factors. As an integrator of diverse growth regulatory signals, mTOR evolved to be a central signaling hub for controlling cellular metabolism and energy homoeostasis, and defects in mTOR signaling are important in the pathologies of cancer, diabetes, and aging. Here we discuss mechanisms by which each mTOR complex might regulate cell survival in response to metabolic and other stresses.Source
Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a008771. doi: 10.1101/cshperspect.a008771. Link to article on publisher's site
DOI
10.1101/cshperspect.a008771Permanent Link to this Item
http://hdl.handle.net/20.500.14038/33509PubMed ID
23124837Related Resources
ae974a485f413a2113503eed53cd6c53
10.1101/cshperspect.a008771