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    mTOR-dependent cell survival mechanisms

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    Authors
    Hung, Chien-Min
    Garcia-Haro, Luisa
    Sparks, Cynthia A.
    Guertin, David A.
    Student Authors
    Chien-Min Hung
    UMass Chan Affiliations
    Program in Molecular Medicine
    Document Type
    Journal Article
    Publication Date
    2012-12-01
    Keywords
    Biochemistry
    Cellular and Molecular Physiology
    
    Metadata
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504431/
    Abstract
    The mechanistic target of rapamycin (mTOR) kinase is a conserved regulator of cell growth, proliferation, and survival. In cells, mTOR is the catalytic subunit of two complexes called mTORC1 and mTORC2, which have distinct upstream regulatory signals and downstream substrates. mTORC1 directly senses cellular nutrient availability while indirectly sensing circulating nutrients through growth factor signaling pathways. Cellular stresses that restrict growth also impinge on mTORC1 activity. mTORC2 is less well understood and appears only to sense growth factors. As an integrator of diverse growth regulatory signals, mTOR evolved to be a central signaling hub for controlling cellular metabolism and energy homoeostasis, and defects in mTOR signaling are important in the pathologies of cancer, diabetes, and aging. Here we discuss mechanisms by which each mTOR complex might regulate cell survival in response to metabolic and other stresses.
    Source

    Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a008771. doi: 10.1101/cshperspect.a008771. Link to article on publisher's site

    DOI
    10.1101/cshperspect.a008771
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/33509
    PubMed ID
    23124837
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1101/cshperspect.a008771
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