Heterologous immunity: immunopathology, autoimmunity and protection during viral infections
AuthorsSelin, Liisa K.
Wlodarczyk, Myriam F.
Kraft, Anke R.M.
Kenney, Laurie L.
Student AuthorsLaurie L. Kenney
UMass Chan AffiliationsDepartment of Pathology
Document TypeJournal Article
Immunology of Infectious Disease
MetadataShow full item record
AbstractHeterologous immunity is a common phenomenon present in all infections. Most of the time it is beneficial, mediating protective immunity, but in some individuals that have the wrong crossreactive response it leads to a cascade of events that result in severe immunopathology. Infections have been associated with autoimmune diseases such as diabetes, multiple sclerosis and lupus erythematosis, but also with unusual autoimmune like pathologies where the immune system appears dysregulated, such as, sarcoidosis, colitis, panniculitis, bronchiolitis obliterans, infectious mononucleosis and even chronic fatigue syndrome. Here we review the evidence that to better understand these autoreactive pathologies it requires an evaluation of how T cells are regulated and evolve during sequential infections with different pathogens under the influence of heterologous immunity.
Autoimmunity. 2011 Jun;44(4):328-47. doi: 10.3109/08916934.2011.523277. Epub 2011 Jan 20. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/33515